- Basic information
- CohesinDB ID: CDBP00419141
- Locus: chr21-38301072-38308873
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Data sourse: ENCSR501LQA, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, ENCSR000ECS, ENCSR330ELC, GSE108869, GSE165895, ENCSR000EFJ, GSE86191, GSE138405, GSE101921, ENCSR806UKK, GSE135093, GSE120943, GSE206145-NatGen2015, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE98367, ENCSR193NSH, ENCSR768DOX, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, GSE38395, GSE105004, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR000HPG, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE126755, ENCSR748MVX
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Cell type: HuCC-T1, RPE, HMEC, Fibroblast, HEKn, HeLa-S3, hLCL, IMR-90, K-562, HFFc6, Monocytes, SK-N-SH, Macrophage, Hela-Kyoto, HCT-116, HEK293T, A-549, HUVEC, HeLa, Neutrophil
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 26% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.778
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
76% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 36%,
"5_TxWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, CBX5, SOX2, NME2, XBP1, FOXA1, MLL4, ATF3, NFIC, BMI1, ZFP64, ZNF362, ZBTB44, CHD7, RUNX3, PRDM1, ZNF189, TP63, ZSCAN4, JMJD1C, MYOG, MAF, ELF1, TRIM28, ETV1, SNAI2, ESR1, TP73, JUN, TCF12, CTCF, EP300, MNT, GATA6, SOX5, IRF4, E2F1, TEAD4, FOXA3, TFAP2C, POU2F2, CHD8, ZSCAN5D, POU5F1, BRD3, MYCN, MTA2, ZBTB48, ZSCAN5A, STAT1, MLLT3, DDX5, HNF4G, ERG, ETS1, MYC, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, XRCC5, UBN1, NFE2, RCOR1, DACH1, VDR, ZNF750, NR3C1, CEBPB, STAT5B, KMT2A, CREB1, EZH2, ZNF652, GABPB1, ZHX2, SPI1, IRF1, GATA2, SSRP1, SIX2, FLI1, NFIL3, MYF5, ETV5, RUNX1, SMC1A, MAFG, CEBPA, EZH2phosphoT487, AFF4, ZFX, POU4F2, SMAD3, CBX8, SMARCC1, ZBTB2, ZNF384, CREBBP, NOTCH1, RUNX2, CDK6, GATA4, OSR2, PBX4, ARNT, SMAD4, ETV6, PBX3, FOS, CHD1, MED1, GMEB1, MYB, ZMYM3, PIAS1, SUPT16H, C11orf30, NCOA1, MAFK, SP1, BCL11A, NIPBL, HNF4A, ARID2, REST, TCF3, FOXP1, SMC3, ELL2, ETV4, PPARG, FOXA2, ZNF316, TBL1X, SS18, NFATC1, WT1, MAFF, FOXF1, ZBTB33, CDK9, BCL3, KDM1A, YY1, RELA, SP140, ZFP36, HIF1A, GATA3, BATF, TAL1, MAX, MAF1, SPIB, GATA1, ZNF143, NCOA3, NR2F2, NEUROG2, KDM5B, TP53, PKNOX1, MYOD1, PHOX2B, ELF3, BRD2, TBX21, BHLHE40, AR, EGR1, HSF1, ZBTB26, NOTCH3, JUND, BRD4, RNF2, CUX1, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ15,KCNJ6
- Function elements
- Human SNPs: Core_binding_factor_acute_myeloid_leukemia
- Number of somatic mutations (coding): 181
- Number of somatic mutations (non-coding): 63
- Related genes and loops