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Basic information

CohesinDB ID: CDBP00419144

Locus: chr21-38318023-38329470

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE103477, GSE111537, GSE108869, GSE165895, ENCSR000EFJ, GSE93080, GSE67783, GSE138405, GSE206145-NatGen2015, GSE135093, GSE120943, GSE112028, ENCSR703TNG, GSE98367, GSE206145, ENCSR000EHX, GSE55407, ENCSR000BTQ, ENCSR000HPG, ENCSR000EDE, GSE68388, GSE126990, GSE50893, ENCSR000ECS, GSE73207

Cell type: Liver, HuCC-T1, RPE, GM2630, Fibroblast, HeLa-S3, GM2255, IMR-90, HFFc6, Monocytes, TF-1, GM12878, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, THP-1, Macrophage, MCF-7, Hela-Kyoto, HEK293T, OCI-AML-3, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 15% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.744

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 76% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 35%, "7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ZNF384, TRP47, OGG1, SP140, ZBTB48

Target gene symbol (double-evidenced CRMs): TTC3,KCNJ6

Function elements

Human SNPs: Height

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 40

Related genes and loops

Related gene: ENSG00000182670, ENSG00000157542,

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Deatailed information for cohesin site CDBP00419144