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Basic information

CohesinDB ID: CDBP00419146

Locus: chr21-38333133-38335676

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE165895, GSE138405, GSE67783, GSE86191, GSE76893, GSE101921, GSE135093, GSE206145-NatGen2015, GSE120943, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE93080, GSE94872, ENCSR000EEG, GSE98367, ENCSR193NSH, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR495WGO, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE55407, ENCSR000HPG, ENCSR676MJK, GSE111913, GSE155324, ENCSR054FKH, ENCSR000EDE, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, HeLa, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 44% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.356

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 76% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 62%, "14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, SKI, TRP47, CBFA2T2, SMC1A, FOXA2, ZNF263, TBL1X, POU5F1, MYCN, ZFX, STAG2, XBP1, ZSCAN5D, WT1, SMAD3, STAT1, FOXA1, ZBTB48, SRF, TET2, SUZ12, PBX2, YY1, RELA, ZBTB2, ZNF384, ETS1, MYC, RUNX2, SMARCA4, ATF3, RAD21, SP140, ARNT, HIF1A, GRHL3, RXRA, ATF2, STAT3, MAX, CBFA2T3, NR2C1, NRIP1, MITF, MED1, PLAG1, KLF4, CEBPB, NCOA3, GFI1B, TRIM28, NEUROG2, NR2F1, KDM5B, EZH2, ESR1, BMPR1A, GRHL2, NFKB1, EBF3, CTCF, JUN, USF1, SP1, SPI1, HNF4A, AR, BHLHE40, REST, HSF1, NR2C2, BRD4, JUND, MAZ, SMC1, SMC3, TBX2, STAG1, TFAP2C

Target gene symbol (double-evidenced CRMs): KCNJ15,TTC3,KCNJ6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 13

Related genes and loops

Related gene: ENSG00000182670, ENSG00000157542, ENSG00000157551,

eachgene

Deatailed information for cohesin site CDBP00419146