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Basic information

CohesinDB ID: CDBP00419150

Locus: chr21-38348297-38360784

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 88% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.089

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 76% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 26%, "15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, ZNF391, ZSCAN5C, SOX2, PATZ1, FOXA1, ZNF101, SUZ12, PBX2, KDM3A, HNRNPK, HDGF, INSM2, NFIC, ATF3, ZFP64, ZNF362, BMI1, CHD7, ZBTB44, PRDM1, ZNF444, KLF14, CBFB, ZNF273, ZNF189, MZF1, TP63, ZNF467, MAF, ZNF629, JMJD1C, TEAD1, TRIM28, ELF1, KLF6, ETV1, BCLAF1, KLF10, LMO2, SAP30, ESR1, HNF1B, SNAI2, USF2, ZNF561, JUN, TCF12, CTCF, EP300, KLF1, GATA6, RYBP, SOX4, DPF2, E2F6, IRF4, RFX5, GLI4, DEK, ZNF512B, E2F1, ZNF528, ZNF350, SMC1, TEAD4, GLIS1, NANOG, CHD8, BRD1, BRD3, ZNF263, MYCN, POU5F1, TOP2A, CTBP1, ZSCAN21, ZNF317, ZBTB17, ZBTB48, STAT1, MTA2, DUX4, SRF, ZSCAN5A, NBN, ERG2, TBP, ERG, ZBTB21, HOXC5, OGG1, MYC, MCM5, SMARCA4, TSHZ1, HOMEZ, RAD21, LHX2, GRHL3, RXRA, NKX2-1, GABPA, STAT3, XRCC5, UBN1, IKZF1, NFE2, RCOR1, ZNF639, NR3C1, CEBPB, ZNF501, ZNF750, KMT2A, CREB1, EZH2, KLF8, ARHGAP35, JMJD6, GRHL2, EBF3, ZHX2, SPI1, EHF, IRF1, KLF17, HDAC2, GATA2, SSRP1, ZNF182, SIX2, FLI1, ZNF766, RELB, HCFC1R1, MRTFB, ZNF554, CC2D1A, RUNX1, CBX1, SMC1A, CEBPA, EZH2phosphoT487, NKX2-2, SIN3A, ZFX, POU4F2, SMAD3, PCBP2, REPIN1, TET2, ERG3, ZNF654, ZNF513, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZNF35, RUNX2, SMAD2, OSR2, ZNF184, SP3, NRF1, ARNT, PBX4, ATF2, PRDM9, ZNF518A, ZEB2, PBX3, ZNF10, FOS, CHD1, SNRNP70, SMARCB1, MED1, ZEB1, TEAD3, ZXDB, MYB, ZNF680, PIAS1, SMAD1, SUPT16H, SETDB1, MAFK, BCL11A, NIPBL, SP1, HNF4A, ARID2, REST, ZHX1, ATF7, ASH2L, PHIP, BCOR, FOXP1, TCF3, PRDM6, AATF, SMC3, ELL2, NCOR2, ZNF34, STAG1, STAG2, ZNF394, PAX7, SKI, TRP47, MEF2B, FOXA2, TBL1X, EBF1, CHD2, SS18, ZNF207, ZNF600, ZNF692, WT1, ZNF30, ZNF574, CDK9, HOXB13, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, MCM3, BRCA1, SP140, ZFP36, PCGF1, SKIL, OTX2, GATA3, TAL1, MAX, SPIB, ZNF143, KLF4, ZNF592, SP7, ZNF512, TCF7L2, KDM5B, TP53, PKNOX1, ZNF213, NFKB1, MYOD1, PHOX2B, ELF3, BRD2, TBX21, BHLHE40, AR, PAX3-FOXO1, RXR, ZNF324, RBAK, ZNF366, ZBTB42, HEXIM1, HSF1, MYNN, IKZF2, BRD4, JUND, SCRT1, ILF3, RNF2, MAZ, ZBTB26, ZSCAN23, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): HLCS,KCNJ6,ERG,TTC3,PSMG1

Function elements

Human SNPs: Metabolite_levels_(HVA)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 98

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157542, ENSG00000157554, ENSG00000183527,

eachgene

Deatailed information for cohesin site CDBP00419150