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Basic information

CohesinDB ID: CDBP00419160

Locus: chr21-38390009-38390598

Data sourse: GSE138405, ENCSR000ECS

Cell type: HeLa-S3, Hela-Kyoto

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SMC3,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 76% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 49%, "14_ReprPCWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SOX2, MEIS2, XBP1, FOXA1, LEO1, PBX2, TFAP4, LYL1, ATF3, NFIC, ZFP64, PRDM1, ATF4, CBFB, MECOM, SMARCE1, MITF, CDX2, JMJD1C, MAF, ZNF629, TRIM28, ETV1, SNAI2, LMO2, ESR1, CTCF, TCF12, JUN, EP300, ARID5B, BAF155, LMO1, ZBTB20, TRIM24, ZNF350, SMC1, TEAD4, KMT2B, TFAP2C, RBPJ, NANOG, CHD8, ZSCAN5D, MYCN, CDK7, RUNX1T1, TOP2A, CTBP1, ZNF317, ZBTB17, ZBTB48, DUX4, STAT1, ERG, ZBTB21, PBX1, ASCL1, ETS1, MYC, SMARCA4, RAD21, PROX1, GABPA, APC, STAT3, NKX3-1, IKZF1, NFE2, RCOR1, NR3C1, CEBPB, KMT2A, EZH2, KLF8, EBF3, SPI1, HDAC2, GATA2, INTS13, FLI1, NCOA2, RUNX1, SMC1A, CEBPA, SIN3A, ZFX, SMAD3, RARA, CREBBP, NOTCH1, ZNF384, RUNX2, PBX4, ARNT, SOX11, ATF2, HMGB2, ZNF518A, PBX3, FOS, CDK8, SUPT5H, MED1, ZEB1, CEBPD, MYB, ZMYM3, PIAS1, EVI1, USF1, BCL11A, NR4A1, REST, ARID1A, RBM25, ATF7, POU2F3, ASH2L, TCF3, FOXP1, SMC3, MLLT1, STAG1, SKI, PPARG, TBL1X, FOXA2, EBF1, MEIS1, SS18, ZNF692, WT1, ESR2, FOXF1, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, ZNF19, JUNB, ISL1, SP140, TCF4, HIF1A, ZFP36, GATA3, TAL1, MAX, ZNF143, GATA1, HAND2, PLAG1, TLE3, ZFP69B, BCL11B, CEBPG, NCOA3, NR2F2, ZNF768, MYOD1, PHOX2B, BRD2, TBX21, AR, ZBTB16, ZNF366, MAML3, HSF1, NCOR1, NOTCH3, BRD4, JUND, CUX1, MAZ, FOSL2

Target gene symbol (double-evidenced CRMs): KCNJ6,ERG,B3GALT5,PSMG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 30

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000157542, ENSG00000157554, ENSG00000183527, ENSG00000183778,

eachgene

Deatailed information for cohesin site CDBP00419160