- Basic information
- CohesinDB ID: CDBP00419182
- Locus: chr21-38457118-38460911
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Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE25021, GSE108869, GSE165895, ENCSR917QNE, GSE67783, GSE138405, GSE101921, GSE206145-NatGen2015, ENCSR703TNG, GSE94872, GSE206145, GSE85526, ENCSR000BTQ, GSE105004, ENCSR853VWZ, GSE111913, ENCSR000EDE, GSE126990, ENCSR000ECS
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Cell type: MCF-7, RPE, Fibroblast, Hela-Kyoto, HEKn, A-549, HUVEC, HCAEC, HeLa-S3, HeLa, SK-N-SH, RT-112, Liver, HSPC, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.833
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
76% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 38%,
"7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, FOSL1, PGR, SOX2, XBP1, FOXA1, LEO1, ATF3, NFIC, CHD7, PRDM1, SMARCE1, TP63, ZNF506, TEAD1, ELF1, ZNF573, TRIM28, SNAI2, NFE2L2, ZNF217, ESR1, TP73, USF2, JUN, CTCF, TCF12, BAF155, EP300, ZNF157, GATA6, DPF2, SOX4, RFX5, DEK, E2F4, ZNF350, SMC1, TEAD4, TFAP2C, POU2F2, NANOG, CHD8, POU5F1, MYCN, TOP2A, CTBP1, DUX4, ERG2, TBP, HNF4G, ERG, ASCL1, ETS1, MYC, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, UBN1, NKX3-1, NFE2, RCOR1, NR3C1, CEBPB, ESRRA, ZNF750, CREB1, EZH2, GRHL2, SPI1, EHF, HDAC2, GATA2, ZNF777, FLI1, MXI1, MRTFB, RUNX1, CBX1, SMC1A, CEBPA, SIN3A, ZFX, AFF4, SMAD3, CREBBP, RUNX2, ARNT, NRF1, HMGB2, PBX3, FOS, MED1, CEBPD, SCRT2, PIAS1, MAFK, SP1, BCL11A, HNF4A, REST, ZHX1, ZNF548, CTBP2, MBD2, SMC3, ELL2, STAG1, ZNF316, FOXA2, CHD2, NFATC1, WT1, MAFF, ZBTB33, HOXB13, KDM1A, YY1, RELA, JUNB, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, TLE3, CEBPG, NR2F2, TCF7L2, KDM5B, ZNF334, NFKB1, AR, TAF1, RXR, EGR1, SCRT1, BRD4, JUND, CLOCK, CUX1, MAZ, BRCA1, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 165
- Number of somatic mutations (non-coding): 0
- Related genes and loops