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Basic information

CohesinDB ID: CDBP00419203

Locus: chr21-38503073-38508323

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE73207, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, SC, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 76% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.178

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 27%, "15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, ZNF660, ZSCAN5C, SOX2, NME2, XBP1, FOXA1, MLL4, TFAP4, NFIC, CHD7, SMARCE1, PAX5, TP63, ZSCAN4, ZNF736, SFPQ, CDX2, JMJD1C, TEAD1, TRIM28, ELF1, LMO2, ESR1, OCA2, MLL, PITX3, ZFP91, JUN, TCF12, CTCF, EP300, BAF155, KLF1, LMO1, PAX8, IRF4, RFX5, SMC1, ZNF280A, TEAD4, FOXA3, GATAD2A, TFAP2C, RBPJ, EED, POU2F2, NANOG, CHD8, ZSCAN5D, MYCN, POU5F1, CDK7, RUNX1T1, BRD1, ZBTB48, STAT1, SRF, MLLT3, SAP130, DDX5, ERG, HOXC5, PBX1, NFKB2, ETS1, MYC, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, PROX1, GABPA, STAT3, XRCC5, UBN1, ZNF614, PRDM14, NKX3-1, RCOR1, HNRNPH1, NFE2, IKZF1, VDR, NR3C1, CEBPB, KMT2A, CREB1, EZH2, GRHL2, EBF3, SPI1, MIXL1, GATA2, MXD3, FLI1, ZNF777, DRAP1, ZGPAT, MRTFB, RUNX1, THAP11, SMC1A, CBX1, CEBPA, NKX2-2, LDB1, AFF4, ZFX, SIN3A, POU4F2, SMAD3, ZNF654, ERG3, TRIM22, SMARCC1, MEF2A, ZBTB2, ZNF35, RARA, ZNF384, NOTCH1, RUNX2, CDK6, ARNT, HMGB2, ATF2, SMAD4, PBX3, FOS, HMGXB4, SUPT5H, CDK8, MED1, TEAD3, MYB, PIAS1, SMAD1, EVI1, STAT5A, MAFK, SP1, BCL11A, HNF4A, NR4A1, IKZF5, REST, POU2F3, TCF3, FOXP1, SMC3, ELL2, NCOR2, STAG1, STAG2, SKI, NELFA, FOXA2, EBF1, MEIS1, NFATC1, GTF2B, MAFF, WT1, MEF2C, ZNF823, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, SP140, ZFP36, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, ZNF143, HAND2, CEBPG, KLF4, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, MED, NFKB1, BRD2, ELF3, TBX21, BHLHE40, AR, ARID4B, ZBTB16, YAP1, EGLN2, HSF1, ZBTB26, NCOR1, BRD4, JUND, SCRT1, ILF3, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): SH3BGR,GET1-SH3BGR,ETS2,PSMG1,GET1,BRWD1,LCA5L,ERG

Function elements

Human SNPs: White_blood_cell_count

Number of somatic mutations (coding): 252

Number of somatic mutations (non-coding): 30

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000185658, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000185437,

eachgene

Deatailed information for cohesin site CDBP00419203