- Basic information
- CohesinDB ID: CDBP00419235
- Locus: chr21-38612552-38615670
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE103477, GSE25021, GSE131606, GSE108869, GSE115602, ENCSR000EFJ, ENCSR000BTU, ENCSR917QNE, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, ENCSR703TNG, GSE94872, GSE206145, ENCSR000ECE, ENCSR000BTQ, GSE129526
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Cell type: MCF-7, H1-hESC, HMEC, Fibroblast, HCT-116, Hela-Kyoto, MDM, RPE, Ishikawa, HUVEC, HeLa-S3, IMR-90, SK-N-SH, Liver, HSPC, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.822
- Subunit: SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
89% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 51%,
"14_ReprPCWk": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, AHRR, PGR, NANOG, SMC1A, ZSCAN5D, EZH2phosphoT487, MYCN, RUNX1T1, SIN3A, ZFX, STAG2, ERF, XBP1, MAFF, ZSCAN5A, ZBTB48, FOXA1, WT1, HOXB13, ERG, YY1, RELA, CREBBP, MYC, CDK6, RAD21, SP140, GRHL3, HIF1A, GATA3, SMC3, STAT3, NRIP1, NKX3-1, GATA1, ZNF143, ZNF449, HDAC3, TLE3, KLF4, NR3C1, NCOA3, NR2F2, TEAD1, CREB1, TCF7L2, NR2F1, EZH2, PIAS1, ESR1, MYOD1, CTCF, MAFK, BAF155, AR, GATA6, HDAC2, GATA2, ARID1A, ASH2L, CTBP2, FOXP1, MAZ, NCOA2, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 405
- Number of somatic mutations (non-coding): 0
- Related genes and loops