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Basic information

CohesinDB ID: CDBP00419244

Locus: chr21-38649184-38649471

Data sourse: GSE206145, GSE206145-NatGen2015

Cell type: RPE, Fibroblast

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 49%, "15_Quies": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: SOX2, XBP1, FOXA1, ZFHX2, ATF3, NFIC, CHD7, TP63, KLF6, SNAI2, LMO2, ESR1, TP73, USF2, JUN, TCF12, CTCF, EP300, SOX4, TEAD4, POU2F2, CHD8, POU5F1, MYCN, TOP2A, DUX4, ZBTB48, STAT1, ERG2, HOXC5, OGG1, MYC, SMARCA4, RXRA, STAT3, XRCC5, RCOR1, NFE2, NR3C1, CEBPB, ZNF750, CREB1, EZH2, SPI1, ATF1, RUNX1, SMC1A, EZH2phosphoT487, SIN3A, ZFX, SMAD3, TET2, ERG3, CBX8, TWIST1, SMARCC1, MEF2A, ZNF384, RUNX2, CDK6, PBX4, DAXX, NRF1, SOX11, ATF2, PBX3, FOS, CHD1, MED1, C11orf30, MAFK, USF1, ATF7, PCGF2, SMC3, STAG1, FOXA2, CREM, SS18, ZSCAN16, MAFF, WT1, ZBTB33, RELA, JUNB, AHR, SP140, ZFP36, HIF1A, GATA3, TAL1, MAX, ZNF143, KLF4, TP53, NFKB1, EGR2, BRD2, BHLHE40, AR, EGR1, RNF2, BRD4, JUND, CLOCK, MAZ, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): ERG,B3GALT5

Function elements

Human SNPs: .

Number of somatic mutations (coding): 35

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157554, ENSG00000183778,

eachgene

Deatailed information for cohesin site CDBP00419244