- Basic information
- CohesinDB ID: CDBP00419246
- Locus: chr21-38659292-38662622
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE116868, GSE105028, GSE111537, GSE131606, GSE25021, GSE115602, ENCSR000BTU, GSE67783, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE118494, GSE98367, GSE206145, ENCSR000BTQ, GSE111913, GSE126990
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Cell type: CVB-hiPSC, CVI-hiPSC, H9-hESC, RPE, Fibroblast, Ishikawa, IMR-90, DKO, H1-hESC, Monocytes, MB157, RT-112, HeLa-Tet-On, Macrophage, MCF-7, Hela-Kyoto, HCT-116, HEK293T, HCAEC, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.767
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
89% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"13_ReprPC": 29%,
"11_BivFlnk": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, FOXO1, TRIM25, FOSL1, PGR, SOX2, NME2, XBP1, PATZ1, FOXA1, SUZ12, RING1B, ZFHX2, ATF3, BMI1, RUNX1T1, ZFP64, ZNF362, CTCFL, CHD7, PRDM1, THAP1, ZNF444, KLF14, MORC2, CBFB, MECOM, ZNF189, PAX5, TP63, ZSCAN4, ZNF467, CDX2, JMJD1C, ELF1, TRIM28, ETV1, SNAI2, NFE2L2, KLF10, ZNF217, ESR1, MED26, ZNF561, CTCF, TCF12, EP300, KLF1, BAF155, ZBTB20, RYBP, E2F6, PRDM4, TRIM24, IRF4, ZBTB42, ZNF423, ZNF512B, E2F1, ZNF528, SMC1, TEAD4, KMT2B, PDX1, TFAP2C, EED, JARID2, GLIS1, POU2F2, NANOG, CHD8, ZSCAN5D, MYCN, ZNF263, TOP2A, POU5F1, ZNF239, CTBP1, ZNF317, ERF, ZBTB48, ZSCAN5A, STAT1, ZBTB17, ZBTB1, ZSCAN21, BRD1, DUX4, ERG2, SP4, TBP, ERG, USP7, OGG1, ZBTB8A, ZNF341, MYC, ETS1, SMARCA4, KDM4A, ZNF2, RAD21, GRHL3, GABPA, STAT3, UBN1, PRDM14, ZNF398, NFE2, RCOR1, VDR, NR3C1, CEBPB, SRSF3, KMT2A, CREB1, EZH2, KLF8, GRHL2, ZNF652, GABPB1, PHF8, ZHX2, SPI1, KLF17, ZBTB14, HDAC2, SSRP1, GATA2, GATAD2B, MXD3, ZNF146, ZNF777, FLI1, ZNF785, MXI1, ZNF76, ZNF554, NCOA2, RUNX1, SMC1A, CEBPA, EZH2phosphoT487, SIRT6, HDAC1, AFF4, ZFX, ZNF335, SIN3A, SMAD3, ZNF770, CBX8, ERG3, NFXL1, ZNF513, SMARCC1, PRDM10, ZNF549, CREBBP, ZNF35, CBX4, ZNF384, RUNX2, CDK6, SMAD2, OSR2, ZNF184, SP3, ARNT, BACH1, NRF1, ZBTB10, ATF2, PRDM9, ZEB2, NCAPH2, SP2, CHD1, FOS, CDK8, MED1, CEBPD, MYB, KLF9, SETDB1, KLF16, USF1, BCL11A, SP1, GSPT2, ARID2, ZBTB7A, ATF7, POU2F3, ASH2L, HNRNPLL, PCGF2, PHIP, BCOR, GLIS2, CTBP2, FOXP1, AATF, PRDM6, SMC3, ELL2, NCOR2, STAG1, ZNF394, PAX7, TRP47, ZNF17, FOXA2, RBBP5, HDAC6, SS18, TBL1X, ZNF600, ZNF692, GTF2B, WT1, FOXF1, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, TARDBP, BRG1, SP140, ZFP36, HIF1A, PCGF1, GATA3, KLF15, TAL1, MAX, MAF1, NRIP1, ZNF143, CBX2, KLF4, SP7, NCOA3, NR2F1, ZNF791, KDM5B, TP53, PKNOX1, ZNF687, ZNF334, ZSCAN22, EGR2, BRD2, ELF3, BHLHE40, AR, PAX3-FOXO1, RXR, ZNF324, ZNF366, HEXIM1, EGR1, TFIIIC, HSF1, NCOR1, NOTCH3, RNF2, ZBTB26, BRD4, RB1, JUND, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): ETS2,KCNJ6,PSMG1,ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 581
- Number of somatic mutations (non-coding): 77
- Related genes and loops
- Related gene:
ENSG00000157542,
ENSG00000157554,
ENSG00000157557,
ENSG00000183527,
- Related loop:
chr21:37800000-37825000~~chr21:38650000-38675000,
chr21:38050000-38075000~~chr21:38650000-38675000,
chr21:38375000-38400000~~chr21:38650000-38675000,
chr21:38500000-38525000~~chr21:38650000-38675000,
chr21:38650000-38675000~~chr21:38750000-38775000,
chr21:38650000-38675000~~chr21:38800000-38825000,
chr21:38650000-38675000~~chr21:39000000-39025000,
chr21:38650000-38675000~~chr21:39125000-39150000,
chr21:38650000-38675000~~chr21:39150000-39175000,