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Basic information

CohesinDB ID: CDBP00419247

Locus: chr21-38664405-38665212

Data sourse: GSE206145-NatGen2015, GSE111913

Cell type: RT-112, Fibroblast

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: Mau2,SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 50%, "13_ReprPC": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, FOXO1, TRIM25, FOSL1, PGR, SOX2, NME2, XBP1, PATZ1, FOXA1, SUZ12, RING1B, ZFHX2, ATF3, BMI1, RUNX1T1, ZFP64, ZNF362, CTCFL, CHD7, PRDM1, THAP1, ZNF444, KLF14, MORC2, CBFB, MECOM, ZNF189, PAX5, TP63, ZSCAN4, ZNF467, CDX2, JMJD1C, ELF1, TRIM28, ETV1, SNAI2, NFE2L2, KLF10, ZNF217, ESR1, MED26, ZNF561, CTCF, TCF12, EP300, KLF1, BAF155, ZBTB20, RYBP, E2F6, PRDM4, TRIM24, IRF4, ZBTB42, ZNF423, ZNF512B, E2F1, ZNF528, SMC1, TEAD4, KMT2B, PDX1, TFAP2C, EED, JARID2, GLIS1, POU2F2, NANOG, CHD8, ZSCAN5D, MYCN, ZNF263, TOP2A, POU5F1, ZNF239, CTBP1, ZNF317, ERF, ZBTB48, ZSCAN5A, STAT1, ZBTB17, ZBTB1, ZSCAN21, BRD1, DUX4, ERG2, SP4, TBP, ERG, USP7, OGG1, ZBTB8A, ZNF341, MYC, ETS1, SMARCA4, KDM4A, ZNF2, RAD21, GRHL3, GABPA, STAT3, UBN1, PRDM14, ZNF398, NFE2, RCOR1, VDR, NR3C1, CEBPB, SRSF3, KMT2A, CREB1, EZH2, KLF8, GRHL2, ZNF652, GABPB1, PHF8, ZHX2, SPI1, KLF17, ZBTB14, HDAC2, SSRP1, GATA2, GATAD2B, MXD3, ZNF146, ZNF777, FLI1, ZNF785, MXI1, ZNF76, ZNF554, NCOA2, RUNX1, SMC1A, CEBPA, EZH2phosphoT487, SIRT6, HDAC1, AFF4, ZFX, ZNF335, SIN3A, SMAD3, ZNF770, CBX8, ERG3, NFXL1, ZNF513, SMARCC1, PRDM10, ZNF549, CREBBP, ZNF35, CBX4, ZNF384, RUNX2, CDK6, SMAD2, OSR2, ZNF184, SP3, ARNT, BACH1, NRF1, ZBTB10, ATF2, PRDM9, ZEB2, NCAPH2, SP2, CHD1, FOS, CDK8, MED1, CEBPD, MYB, KLF9, SETDB1, KLF16, USF1, BCL11A, SP1, GSPT2, ARID2, ZBTB7A, ATF7, POU2F3, ASH2L, HNRNPLL, PCGF2, PHIP, BCOR, GLIS2, CTBP2, FOXP1, AATF, PRDM6, SMC3, ELL2, NCOR2, STAG1, ZNF394, PAX7, TRP47, ZNF17, FOXA2, RBBP5, HDAC6, SS18, TBL1X, ZNF600, ZNF692, GTF2B, WT1, FOXF1, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, TARDBP, BRG1, SP140, ZFP36, HIF1A, PCGF1, GATA3, KLF15, TAL1, MAX, MAF1, NRIP1, ZNF143, CBX2, KLF4, SP7, NCOA3, NR2F1, ZNF791, KDM5B, TP53, PKNOX1, ZNF687, ZNF334, ZSCAN22, EGR2, BRD2, ELF3, BHLHE40, AR, PAX3-FOXO1, RXR, ZNF324, ZNF366, HEXIM1, EGR1, TFIIIC, HSF1, NCOR1, NOTCH3, RNF2, ZBTB26, BRD4, RB1, JUND, MAZ, AHR

Target gene symbol (double-evidenced CRMs): ETS2,ERG,KCNJ6,PSMG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000157542, ENSG00000157554, ENSG00000157557, ENSG00000183527,

eachgene

Deatailed information for cohesin site CDBP00419247