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Basic information

CohesinDB ID: CDBP00419256

Locus: chr21-38698999-38699651

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE131606, GSE108869, ENCSR000EDW, GSE25021, GSE115602, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, GSE94872, ENCSR000EEG, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE97394, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, GSE68388, GSE126990, GSE50893, GSE38411

Cell type: HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, GM2255, BCBL-1, K-562, DKO, H1-hESC, GM18951, SK-N-SH, RT-112, HeLa-Tet-On, THP-1, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HUVEC, HeLa, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 15% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.722

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 43%, "15_Quies": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: GLIS1, POU2F2, CHD8, SMC1A, CBX1, ZNF263, CREM, MYCN, ZFX, POU4F2, XBP1, ZBTB48, ZSCAN5A, WT1, SRF, GATAD1, TRIM22, ERG, YY1, RELA, ZBTB2, AHR, ATF3, MYC, RAD21, ARNT, HIF1A, GRHL3, ZNF48, SMAD4, XRCC5, FOS, HMGXB4, ZNF143, HNRNPH1, CDK8, MED1, NCOA3, TEAD3, CREB1, KLF6, TBL1XR1, ZNF3, ESR1, STAG1, CTCF, BCL11A, SPI1, AR, HDAC2, REST, FLI1, ZBTB26, MAZ, SMC1, ZNF528, SMC3, GATAD2A, ETV5, TFAP2C

Target gene symbol (double-evidenced CRMs): KCNJ6,PSMG1,ERG

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000157542, ENSG00000157554, ENSG00000183527,

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Deatailed information for cohesin site CDBP00419256