- Basic information
- CohesinDB ID: CDBP00419256
- Locus: chr21-38698999-38699651
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE131606, GSE108869, ENCSR000EDW, GSE25021, GSE115602, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, GSE94872, ENCSR000EEG, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE97394, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, GSE68388, GSE126990, GSE50893, GSE38411
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Cell type: HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, GM2255, BCBL-1, K-562, DKO, H1-hESC, GM18951, SK-N-SH, RT-112, HeLa-Tet-On, THP-1, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HUVEC, HeLa, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 15% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.722
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
89% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"14_ReprPCWk": 43%,
"15_Quies": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: GLIS1, POU2F2, CHD8, SMC1A, CBX1, ZNF263, CREM, MYCN, ZFX, POU4F2, XBP1, ZBTB48, ZSCAN5A, WT1, SRF, GATAD1, TRIM22, ERG, YY1, RELA, ZBTB2, AHR, ATF3, MYC, RAD21, ARNT, HIF1A, GRHL3, ZNF48, SMAD4, XRCC5, FOS, HMGXB4, ZNF143, HNRNPH1, CDK8, MED1, NCOA3, TEAD3, CREB1, KLF6, TBL1XR1, ZNF3, ESR1, STAG1, CTCF, BCL11A, SPI1, AR, HDAC2, REST, FLI1, ZBTB26, MAZ, SMC1, ZNF528, SMC3, GATAD2A, ETV5, TFAP2C
- Target gene symbol (double-evidenced CRMs): KCNJ6,PSMG1,ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000157542,
ENSG00000157554,
ENSG00000183527,
- Related loop:
chr21:37725000-37750000~~chr21:38700000-38725000,
chr21:38050000-38075000~~chr21:38675000-38700000,
chr21:38075000-38100000~~chr21:38700000-38725000,
chr21:38150000-38175000~~chr21:38675000-38700000,
chr21:38150000-38175000~~chr21:38700000-38725000,
chr21:38375000-38400000~~chr21:38675000-38700000,
chr21:38375000-38400000~~chr21:38700000-38725000,
chr21:38425000-38450000~~chr21:38700000-38725000,
chr21:38450000-38475000~~chr21:38700000-38725000,
chr21:38475000-38500000~~chr21:38675000-38700000,
chr21:38500000-38525000~~chr21:38675000-38700000,
chr21:38500000-38525000~~chr21:38700000-38725000,
chr21:38525000-38550000~~chr21:38700000-38725000,
chr21:38575000-38600000~~chr21:38675000-38700000,
chr21:38600000-38625000~~chr21:38700000-38725000,
chr21:38675000-38700000~~chr21:39125000-39150000,
chr21:38698410-38700041~~chr21:39136627-39139221,
chr21:38698689-38700039~~chr21:39136191-39139182,
chr21:38698689-38700039~~chr21:39174554-39176142,
chr21:38700000-38725000~~chr21:39050000-39075000,
chr21:38700000-38725000~~chr21:39100000-39125000,
chr21:38700000-38725000~~chr21:39125000-39150000,
chr21:38700000-38725000~~chr21:39150000-39175000,