- Basic information
- CohesinDB ID: CDBP00419275
- Locus: chr21-38750928-38753320
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Data sourse: ENCSR167MTG, GSE67783, GSE72082, GSE86191, GSE98367, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, GSE55407, GSE120943, ENCSR153HNT, GSE111537, GSE126755, GSE165895
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Cell type: RPE, Fibroblast, HCT-116, Monocytes, Hep-G2, THP-1, OCI-AML-3, K-562, Neutrophil, HSPC, Macrophage, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 38%,
"7_Enh": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: ZFX, XBP1, WT1, ZSCAN5A, CBX8, LEO1, ERG, RELA, MYC, SMAD4, ZNF614, FOS, CBX2, TEAD3, RBM39, ESR1, PKNOX1, CTCF, ZNF479, RNF2, SMC3, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): GET1,ERG,GET1-SH3BGR,KCNJ15
- Function elements
- Human SNPs: Body_mass_index
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 17
- Related genes and loops
- Related gene:
ENSG00000157551,
ENSG00000157554,
ENSG00000285815,
ENSG00000182093,
- Related loop:
chr21:34525000-34550000~~chr21:38750000-38775000,
chr21:38250000-38275000~~chr21:38750000-38775000,
chr21:38500000-38525000~~chr21:38750000-38775000,
chr21:38650000-38675000~~chr21:38750000-38775000,
chr21:38725000-38750000~~chr21:38850000-38875000,
chr21:38725000-38750000~~chr21:38875000-38900000,
chr21:38725000-38750000~~chr21:38900000-38925000,
chr21:38725000-38750000~~chr21:38975000-39000000,
chr21:38725000-38750000~~chr21:39100000-39125000,
chr21:38725000-38750000~~chr21:39125000-39150000,
chr21:38725000-38750000~~chr21:39150000-39175000,
chr21:38750000-38775000~~chr21:39100000-39125000,
chr21:38750000-38775000~~chr21:39375000-39400000,