Deatailed information for cohesin site CDBP00419276

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  • Basic information
  • CohesinDB ID: CDBP00419276
  • Locus: chr21-38755256-38758111
  • Data sourse: ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE103477, GSE111537, GSE108869, ENCSR330ELC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE67783, GSE86191, GSE138405, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE98367, ENCSR193NSH, ENCSR879KXD, GSE206145, GSE85526, ENCSR217ELF, GSE55407, GSE129526, ENCSR000HPG, GSE111913, ENCSR000EDE, GSE68388, GSE126990, ENCSR000ECS
  • Cell type: SLK, Liver, HuCC-T1, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, SK-N-SH, RT-112, THP-1, Macrophage, MCF-7, Hela-Kyoto, HCT-116, A-549, OCI-AML-3, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 14% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.767
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 96% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 31%, "7_Enh": 28%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, HMG20A, SOX2, FOXA1, HLF, RXRB, ZFHX2, TFAP4, LYL1, ATF3, NFIC, BMI1, ZNF362, CHD7, MXD4, SMARCE1, ZNF736, ZNF629, JMJD1C, SNAPC1, TEAD1, TRIM28, ELF1, ETV1, NFE2L2, SNAI2, ZNF217, ESR1, MLL, LMO2, JUN, TCF12, CTCF, EP300, E4F1, MNT, DPF2, E2F6, PRDM4, TRIM24, RFX5, RFX3, TEAD4, KMT2B, FOXA3, GATAD2A, PDX1, RBPJ, GLIS1, POU5F1, MYCN, TOP2A, RUNX1T1, CDK7, CTBP1, ZNF317, ZBTB17, SRF, SAP130, ARID3A, TBP, HOXC5, ZBTB21, ERG, ETS1, MYC, EOMES, RFX1, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, PROX1, GABPA, STAT3, XRCC5, NKX3-1, RCOR1, NFE2, ZNF639, NR2F6, VDR, NR3C1, ESRRA, CEBPB, ZNF750, KMT2A, CREB1, ZBTB11, MRTFA, ZHX2, SPI1, EHF, GATA2, FLI1, MXI1, ZGPAT, MRTFB, NFIL3, ZNF554, NFYB, ZIM3, ETV5, RUNX1, THAP11, SMC1A, ZBTB24, CEBPA, MAFG, NKX2-2, HDAC1, AFF4, ZNF335, SIN3A, SMAD3, SMARCC1, PRDM10, MEF2A, CREBBP, RARA, NOTCH1, ZNF35, ZNF384, NFYC, ZNF184, PBX4, DAXX, ARNT, ATF2, PRDM9, ZEB2, NFYA, FOXM1, PBX3, SP2, FOS, CDK8, MAFB, FOXJ2, MED1, TEAD3, DIDO1, CEBPD, MYB, SCRT2, PIAS1, NR1H2, NCOA1, L3MBTL2, C11orf30, ZNF22, MAFK, BCL11A, SP1, NIPBL, REST, RBM25, POU2F3, TCF3, FOXP1, ELL2, ETV4, SKI, PPARG, FOXA2, ZNF316, EBF1, CHD2, SS18, MAFF, ZBTB33, MEF2C, HOXB13, KDM1A, YY1, RELA, TARDBP, JUNB, ZIC2, HIF1A, GATA3, TAL1, MAX, GATA1, CBX2, CEBPG, SP7, NR2F2, TCF7L2, NR2F1, TP53, ZNF687, NFKB1, T, ELF3, BRD2, BHLHE40, AR, ARID4B, TAF1, ZBTB16, RXR, ZBTB26, RNF2, HSF1, BRD4, JUND, SCRT1, CLOCK, NCOR1, CUX1, MEF2D, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): GET1,ERG,GET1-SH3BGR,KCNJ15
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 11
  • Related genes and loops
  • Related gene: ENSG00000157551, ENSG00000157554, ENSG00000285815, ENSG00000182093,
  • Related loop: chr21:34525000-34550000~~chr21:38750000-38775000, chr21:38250000-38275000~~chr21:38750000-38775000, chr21:38500000-38525000~~chr21:38750000-38775000, chr21:38650000-38675000~~chr21:38750000-38775000, chr21:38750000-38775000~~chr21:39100000-39125000, chr21:38750000-38775000~~chr21:39375000-39400000,
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