- Basic information
- CohesinDB ID: CDBP00419287
- Locus: chr21-38772940-38775249
-
Data sourse: GSE104888, ENCSR000BSB, ENCSR501LQA, ENCSR760NPX, ENCSR150EFU, ENCSR000ECS, GSE121355, GSE131606, GSE108869, GSE165895, ENCSR000EFJ, GSE67783, GSE86191, GSE138405, GSE101921, ENCSR806UKK, GSE135093, GSE120943, GSE206145-NatGen2015, ENCSR895JMI, ENCSR193NSH, ENCSR768DOX, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR217ELF, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR000EDE, GSE68388, ENCSR748MVX
-
Cell type: RPE, HMEC, Fibroblast, HCT-116, Hela-Kyoto, Monocytes, A-549, HeLa-S3, IMR-90, HSPC, RT-112, HFFc6, HuCC-T1, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 16% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.844
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 38%,
"7_Enh": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SMARCA2, E2F7, SOX2, NME2, XBP1, FOXA1, HLF, LEO1, ZFHX2, ATF3, NFIC, ZFP64, CHD7, RUNX3, KLF14, ZNF273, ZNF189, PAX5, BACH2, CDX2, MAF, ZNF629, ELF1, TRIM28, TEAD1, KLF6, SNAI2, NFE2L2, ESR1, OCA2, MLL, HNF1B, USF2, CTCF, JUN, TCF12, EP300, ZBTB20, MNT, DPF2, SOX4, E2F6, TRIM24, RFX5, IRF4, E2F1, TEAD4, FOXA3, GATAD2A, PDX1, RBPJ, EED, TFAP2C, POU2F2, CHD8, ZSCAN5D, ZNF263, MYCN, ZNF778, KDM4C, ZBTB17, ZBTB48, ZSCAN5A, STAT1, SAP130, ERG2, HOXC5, PBX1, SMARCC2, MYC, SMARCA4, RAD21, FOXP2, GRHL3, PROX1, NKX2-1, BATF3, STAT3, XRCC5, UBN1, ZNF398, IKZF1, RCOR1, ZNF639, VDR, NR3C1, CEBPB, KMT2A, EZH2, EBF3, ZHX2, SPI1, IRF1, KLF17, INTS13, GATA2, ZNF644, FLI1, MXI1, ZGPAT, MRTFB, ZNF554, RUNX1, SMC1A, CEBPA, EZH2phosphoT487, SIN3A, ZFX, ZNF534, ZNF132, SMAD3, TET2, ERG3, CBX8, SMARCC1, TWIST1, RARA, CREBBP, RUNX2, GATA4, ZNF184, GR, NRF1, PBX4, DAXX, HMGB2, ATF2, PRDM9, ETV6, PBX3, FOS, SMARCB1, CHD1, CDK8, MED1, ZEB1, TEAD3, MYB, NR1H2, SETDB1, STAT5A, USF1, NIPBL, MAFK, SP1, BCL11A, GSPT2, IKZF5, ZHX1, PHIP, TCF3, FOXP1, SMC3, HMGB1, STAG1, MEF2B, PPARG, FOXA2, CBX3, EBF1, CREM, SS18, ZNF600, ZNF692, ZSCAN16, ZBED1, MAFF, WT1, FOXF1, BCL3, KDM1A, ZNF19, RELA, YY1, JUNB, SP140, TCF4, ZFP36, HIF1A, ZNF311, GATA3, BATF, MGA, TAL1, MAX, ZNF143, GATA1, PLAG1, KLF4, SP7, NCOA3, NR2F2, NEUROG2, TCF7L2, NR2F1, TP53, MED, NFKB1, MYOD1, EGR2, ELF3, BRD2, BHLHE40, AR, TAF1, RNF2, IKZF2, BRD4, JUND, NOTCH3, MAZ, BRCA1, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ6,GET1-SH3BGR,ERG,GET1,KCNJ15
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 15
- Related genes and loops
- Related gene:
ENSG00000157542,
ENSG00000157551,
ENSG00000157554,
ENSG00000285815,
ENSG00000182093,
- Related loop:
chr21:34525000-34550000~~chr21:38750000-38775000,
chr21:37850000-37875000~~chr21:38775000-38800000,
chr21:38250000-38275000~~chr21:38750000-38775000,
chr21:38500000-38525000~~chr21:38750000-38775000,
chr21:38650000-38675000~~chr21:38750000-38775000,
chr21:38750000-38775000~~chr21:39100000-39125000,
chr21:38750000-38775000~~chr21:39375000-39400000,
chr21:38766321-38768490~~chr21:38787063-38788773,
chr21:38766338-38769337~~chr21:38787166-38788740,
chr21:38768038-38770235~~chr21:38795780-38799297,
chr21:38775000-38800000~~chr21:39375000-39400000,
chr21:38775000-38800000~~chr21:41350000-41375000,
chr21:38775000-38800000~~chr21:43325000-43350000,