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Basic information

CohesinDB ID: CDBP00419295

Locus: chr21-38793941-38799351

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, ENCSR054FKH, ENCSR748MVX, ENCSR000ECS, ENCSR000BLD, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE25021, ENCSR000EAC, GSE76893, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, SLK, GM19240, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, Macrophage, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM19238, HeLa, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 49% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.478

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 36%, "7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, MLL4, KDM3A, HDGF, TEAD1, PITX3, ZNF561, E4F1, SOX5, DEK, E2F4, ZNF528, GATAD2A, ZNF263, POU5F1, BRD3, CTBP1, STAT1, SAP130, ERG, PAX6, ZBTB8A, NFKB2, EZH1, SMARCA4, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, CREB1, GABPB1, ZHX2, ELF4, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, MXI1, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, TET2, SP5, ZNF549, PRDM10, SMARCC1, ZBTB2, ATF2, SMARCB1, SMAD1, NR1H2, EVI1, MBD1, IKZF5, ELL2, CBFA2T2, CBX3, CREM, CHD2, PAF1, WT1, MEF2C, JUNB, NEUROD1, TCF4, ZFP36, BATF, PLAG1, KLF4, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, PBX2, ATF3, THRB, ZFP64, HNRNPUL1, JMJD1C, ELF1, RBM39, KLF10, CTCF, JUN, TAF3, LMO1, ZBTB20, DPF2, IRF4, ZNF350, PDX1, RBPJ, TFAP2C, MLX, MTA2, ZSCAN21, ZBTB48, ZNF317, ZBTB17, SRF, DDX5, NBN, HOMEZ, RXRA, BATF3, NKX3-1, MIER3, VDR, NR3C1, ESRRA, KMT2A, TBL1XR1, GRHL2, EBF3, NFIL3, CC2D1A, THAP11, CTNNB1, ZBTB24, SOX13, AFF4, ZNF770, ZNF18, SP3, ARNT, DAXX, BACH1, NFIB, ZNF48, HMBOX1, ZEB2, PBX3, MAFB, ZNF10, HMGXB4, ICE2, TEAD3, U2AF1, KLF9, USF1, SP1, BCL11A, ATF7, ASH2L, GLIS2, SMC3, STAG1, STAG2, MLLT1, ZNF394, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KDM1A, ISL1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, CBX2, TP53, NFKB1, ZSCAN22, PHOX2B, PHF5A, BRD2, KAT8, EGR1, RB1, RNF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, PGR, PATZ1, SMAD1-5, UBTF, TFAP4, ATF4, MXD4, ZNF189, SMARCE1, RLF, KLF6, NFE2L2, ESR1, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, SMARCC2, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, ZNF652, SPI1, HDAC2, NCOA2, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF35, CREBBP, NFYC, ZNF384, SMAD4, CBFA2T3, CDK8, SNRNP70, ZEB1, ZMYM3, NCOA1, GTF3C2, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, ZNF692, ZNF30, ZNF574, RELA, TARDBP, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, PAX3-FOXO1, AR, ZNF324, DMAP1, AHR, FOSL2, HMG20A, MEIS2, ZFHX2, NFIC, PRDM1, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, RCOR2, HNF1B, USF2, TCF12, EP300, GATA6, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, CHD8, BRD1, MYCN, RUNX1T1, GATAD1, ARID3A, ASCL1, ZNF341, EOMES, RAD21, PROX1, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF750, TFE3, EHF, IRF1, ZGPAT, PTBP1, SMC1A, CBX1, MAFG, ZNF335, ZFX, SMAD3, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, NRF1, FOS, MED1, ZNF558, MYB, CEBPD, ZNF3, KLF16, NIPBL, ZBTB7A, PHIP, SKI, ZNF283, KLF13, FOXA2, ZNF600, MIER2, ZBTB33, YY1, SP140, HIF1A, BHLHE22, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZBTB40, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): GET1-SH3BGR,KCNJ6,GET1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 36

Related genes and loops

Related gene: ENSG00000157542, ENSG00000285815, ENSG00000182093,

eachgene

Deatailed information for cohesin site CDBP00419295