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Basic information

CohesinDB ID: CDBP00419296

Locus: chr21-38800466-38816528

Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE64758, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 76% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.233

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "2_TssAFlnk": 16%, "7_Enh": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ARID5B, E4F1, ZNF157, SOX5, DEK, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, HHEX, POU5F1, BRD3, CTBP1, ZMYND11, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RFX1, FOXK2, UBN1, ZNF398, RCOR1, NUFIP1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, HCFC1, MXI1, ZNF785, RELB, EP400, RUNX1, CEBPA, HDAC1, NKX2-2, REPIN1, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, IKZF5, ARID2, RBM25, AFF1, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, ZFP69B, BCL11B, IRF5, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, HNF1A, XBP1, KDM4B, ZNF101, PBX2, SRSF4, ZNF596, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, BACH2, ZNF467, MAF, JMJD1C, INTS11, ELF1, MYOG, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, CTCF, TAF3, L3MBTL4, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MLX, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, CHD4, PBX1, ONECUT1, KDM4A, HOMEZ, ZNF2, TSHZ1, FOXP2, RXRA, BATF3, PRDM14, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, LDB1, EZH2phosphoT487, SOX13, AFF4, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, DAXX, BACH1, NFIB, ZNF48, PRDM9, ZEB2, HMBOX1, PBX3, ETV6, NCAPH2, ZNF10, HMGXB4, MAFB, TEAD3, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, ZNF548, CTBP2, GLIS2, PRDM6, SMC3, STAG1, STAG2, MLLT1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, KLF7, KDM1A, ZKSCAN1, BRG1, ISL1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF645, ZNF334, NFKB1, ZSCAN22, ZNF140, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, SMAD4.1D12, TBX2, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, RING1B, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, ZNF524, KLF1, ZNF695, SOX9, SOX4, E2F6, TRIM24, RFX5, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZBTB1, ASH1L, ZSCAN5A, ELK4, ZMYND8, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, PHF21A, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, GFI1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF777, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, NFXL1, MEF2A, RARA, ZNF384, CREBBP, NFYC, TAF15, ZNF35, ZNF169, ZNF133, SMAD4, ZNF518A, CBFA2T3, CDK8, ZEB1, ZNF264, ZMYM3, SUPT16H, NCOA1, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF574, TCF7, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, NEUROG2, PKNOX1, ZNF547, T, AR, PAX3-FOXO1, ZNF324, HEXIM1, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, ZSCAN5C, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, SFMBT1, INSM2, NFIC, ZNF362, CTCFL, ZBTB5, PRDM1, KLF14, GLYR1, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, MLL, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, GMEB2, ARID3A, MIER1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF501, JMJD6, FEZF1, TFE3, HBP1, EHF, IRF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, PCBP2, NMYC, TWIST1, ZNF701, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, NRF1, FOS, CHD1, SUPT5H, TGIF2, MED1, CEBPD, MYB, SCRT2, KDM6B, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, ZNF283, PAX7, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF449, GATA1, HAND2, CEBPG, SP7, NR2F2, ZNF512, ZNF687, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, MYNN, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): GET1,ETS2,HMGN1,GET1-SH3BGR,B3GALT5,ERG,BRWD1,KCNJ6,SH3BGR,PSMG1,LCA5L

Function elements

Human SNPs: Non-small_cell_lung_cancer_(survival)

Number of somatic mutations (coding): 350

Number of somatic mutations (non-coding): 58

Related genes and loops

Related gene: ENSG00000157542, ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000185658, ENSG00000205581, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000185437, ENSG00000183778,

eachgene

Deatailed information for cohesin site CDBP00419296