- Basic information
- CohesinDB ID: CDBP00419297
- Locus: chr21-38816889-38818881
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Data sourse: ENCSR230ZWH, GSE72082, ENCSR501LQA, ENCSR000ECS, GSE131606, ENCSR330ELC, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE67783, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, ENCSR199XBQ, GSE94872, GSE118494, GSE98367, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR217ELF, ENCSR853VWZ, ENCSR944ZCT, ENCSR000HPG, GSE111913, ENCSR000EDE, GSE68388, ENCSR748MVX
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Cell type: MCF-7, Macrophage, RPE, Fibroblast, HCT-116, Hela-Kyoto, Monocytes, A-549, HUVEC, HCAEC, HeLa-S3, IMR-90, HSPC, RT-112, Liver, HFFc6, HuCC-T1, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.800
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 66%,
"6_EnhG": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, ZNF496, HMG20A, E2F7, XBP1, HNF1A, FOXA1, HLF, RBFOX2, LEO1, RXRB, PBX2, KDM3A, HNRNPK, TFAP4, HDGF, TSC22D4, ATF3, NFIC, THRB, ZNF112, CHD7, CBFB, GLYR1, ZNF189, SMARCE1, MXD4, TP63, JMJD1C, MAF, KLF5, TEAD1, TRIM28, KLF6, SNAI2, ETV1, NFE2L2, SMAD5, ESR1, ZNF217, HNF1B, LMO2, HDAC8, RCOR2, USF2, MBD4, KLF10, CTCF, JUN, TCF12, EP300, BAF155, KLF1, MNT, L3MBTL4, SOX5, DPF2, DMAP1, TRIM24, RFX5, DEK, E2F1, SMC1, RFX3, TEAD4, FOXA3, ZNF175, GTF2F1, GATAD2A, TFAP2C, RBPJ, MLX, EED, CHD8, BRD1, MIER3, ZNF263, POU5F1, TOP2A, MYCN, ZSCAN5D, CTBP1, ZMYND11, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ERG2, ARID3A, TBP, HNF4G, ERG, HOXC5, CHD4, ASCL1, OGG1, SMARCC2, ETS1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, MCRS1, GABPA, STAT3, XRCC5, ZNF614, RCOR1, DNMT3B, NR2F6, NFE2, VDR, HNRNPH1, NR3C1, CEBPB, ESRRA, ZNF750, INO80, KMT2A, CREB1, CCAR2, TBL1XR1, BMPR1A, GRHL2, ZNF652, TRPS1, GABPB1, ZHX2, SPI1, TFE3, MIXL1, HBP1, IRF1, KLF17, PCBP1, HDAC2, GATA2, SSRP1, ZNF644, ZNF146, MXD3, FLI1, TCF25, DRAP1, MXI1, ZGPAT, SMARCA5, MRTFB, NCOA2, NFIL3, ETV5, RUNX1, THAP11, CBX1, SMC1A, CEBPA, MAFG, BCL6, SIN3A, ZFX, FIP1L1, SOX13, SMAD3, PCBP2, TET2, ERG3, TBX3, SP5, SMARCC1, TWIST1, MYBL2, RARA, CREBBP, ZXDC, PRPF4, NOTCH1, NFYC, RUNX2, CDK6, GATA4, ZNF384, DAXX, PBX4, ARNT, NRF1, ATF2, ZNF48, SMAD4, ZEB2, PBX3, ZNF10, SUPT5H, FOS, CDK8, SMARCB1, HMGXB4, MED1, TGIF2, SP2, TEAD3, ZEB1, CEBPD, MYB, PML, U2AF1, ZMYM3, PIAS1, ZNF3, NR1H2, SUPT16H, SETDB1, MBD1, RBM22, MAFK, NIPBL, SP1, GSPT2, HNF4A, BCL11A, USF1, ARID2, IKZF5, ARID1A, REST, RBM25, ATF7, ZHX1, ASH2L, CTBP2, PHIP, BCOR, MBD2, FOXP1, AATF, SMC3, NCOR2, STAG1, MLLT1, ETV4, SKI, TRP47, PPARG, FOXA2, AGO1, CREM, CHD2, PAF1, SS18, ZNF44, MIER2, E2F8, WT1, MAFF, MEIS1, FOXF1, ZBTB33, MEF2C, TCF7, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, FOXO3, ZKSCAN1, MPHOSPH8, NEUROD1, JUNB, BRCA1, SP140, TCF4, HIF1A, MCM3, OTX2, GATA3, TAL1, MAX, NRIP1, ZNF143, AGO2, GATA1, CBX2, KLF4, CEBPG, NCOA3, NR2F2, NEUROG2, NR2F1, KDM5B, TCF7L2, TP53, ZNF687, ZBTB6, RUVBL1, ZNF334, NFKB1, MYOD1, EGR2, PHOX2B, PHF5A, BRD2, ELF3, KAT8, BHLHE40, AR, ARID4B, NFKBIZ, ZNF579, ZBTB40, RXR, YAP1, EGLN2, EGR1, ZBTB26, NCOR1, NOTCH3, JUND, BRD4, HSF1, SCRT1, CUX1, MAZ, SMAD4.1D12, ZNF24, ADNP, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): KCNJ6,LCA5L,ERG,HMGN1,PSMG1,GET1,BRWD1,ETS2,GET1-SH3BGR,SH3BGR,B3GALT5
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 148
- Number of somatic mutations (non-coding): 74
- Related genes and loops
- Related gene:
ENSG00000157542,
ENSG00000157554,
ENSG00000157557,
ENSG00000183527,
ENSG00000185658,
ENSG00000205581,
ENSG00000285815,
ENSG00000182093,
ENSG00000157578,
ENSG00000185437,
ENSG00000183778,
- Related loop:
chr21:37850000-37875000~~chr21:38800000-38825000,
chr21:38150000-38175000~~chr21:38800000-38825000,
chr21:38500000-38525000~~chr21:38800000-38825000,
chr21:38650000-38675000~~chr21:38800000-38825000,
chr21:38800000-38825000~~chr21:38900000-38925000,
chr21:38800000-38825000~~chr21:38950000-38975000,
chr21:38800000-38825000~~chr21:38975000-39000000,
chr21:38800000-38825000~~chr21:39000000-39025000,
chr21:38800000-38825000~~chr21:39025000-39050000,
chr21:38800000-38825000~~chr21:39050000-39075000,
chr21:38800000-38825000~~chr21:39075000-39100000,
chr21:38800000-38825000~~chr21:39100000-39125000,
chr21:38800000-38825000~~chr21:39125000-39150000,
chr21:38800000-38825000~~chr21:39175000-39200000,
chr21:38800000-38825000~~chr21:39325000-39350000,
chr21:38800000-38825000~~chr21:39375000-39400000,
chr21:38800000-38825000~~chr21:39425000-39450000,
chr21:38800000-38825000~~chr21:39600000-39625000,
chr21:38810787-38812114~~chr21:39125156-39127107,
chr21:38810787-38812114~~chr21:39174059-39176516,
chr21:38818748-38820756~~chr21:39047115-39049516,
chr21:38818748-38820756~~chr21:39125161-39127067,
chr21:38818748-38820756~~chr21:39136216-39139158,
chr21:38823242-38824815~~chr21:39125156-39127107,