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Basic information

CohesinDB ID: CDBP00419299

Locus: chr21-38823665-38827360

Data sourse: ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE25021, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR917QNE, GSE67783, GSE138405, GSE76893, GSE101921, GSE135093, GSE206145-NatGen2015, GSE120943, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE85526, ENCSR635OSG, ENCSR167MTG, GSE129526, ENCSR000HPG, ENCSR054FKH, GSE68388, GSE126990, GSE126755

Cell type: Macrophage, Hela-Kyoto, Fibroblast, HCT-116, HEKn, Hep-G2, Monocytes, HCAEC, IMR-90, SK-N-SH, Liver, Neutrophil, HSPC, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 11% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 34%, "4_Tx": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, ZNF496, HMG20A, E2F7, XBP1, HNF1A, FOXA1, HLF, RBFOX2, LEO1, RXRB, PBX2, KDM3A, HNRNPK, TFAP4, HDGF, TSC22D4, ATF3, NFIC, THRB, ZNF112, CHD7, CBFB, GLYR1, ZNF189, SMARCE1, MXD4, TP63, JMJD1C, MAF, KLF5, TEAD1, TRIM28, KLF6, SNAI2, ETV1, NFE2L2, SMAD5, ESR1, ZNF217, HNF1B, LMO2, HDAC8, RCOR2, USF2, MBD4, KLF10, CTCF, JUN, TCF12, EP300, BAF155, KLF1, MNT, L3MBTL4, SOX5, DPF2, DMAP1, TRIM24, RFX5, DEK, E2F1, SMC1, RFX3, TEAD4, FOXA3, ZNF175, GTF2F1, GATAD2A, TFAP2C, RBPJ, MLX, EED, CHD8, BRD1, MIER3, ZNF263, POU5F1, TOP2A, MYCN, ZSCAN5D, CTBP1, ZMYND11, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ERG2, ARID3A, TBP, HNF4G, ERG, HOXC5, CHD4, ASCL1, OGG1, SMARCC2, ETS1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, MCRS1, GABPA, STAT3, XRCC5, ZNF614, RCOR1, DNMT3B, NR2F6, NFE2, VDR, HNRNPH1, NR3C1, CEBPB, ESRRA, ZNF750, INO80, KMT2A, CREB1, CCAR2, TBL1XR1, BMPR1A, GRHL2, ZNF652, TRPS1, GABPB1, ZHX2, SPI1, TFE3, MIXL1, HBP1, IRF1, KLF17, PCBP1, HDAC2, GATA2, SSRP1, ZNF644, ZNF146, MXD3, FLI1, TCF25, DRAP1, MXI1, ZGPAT, SMARCA5, MRTFB, NCOA2, NFIL3, ETV5, RUNX1, THAP11, CBX1, SMC1A, CEBPA, MAFG, BCL6, SIN3A, ZFX, FIP1L1, SOX13, SMAD3, PCBP2, TET2, ERG3, TBX3, SP5, SMARCC1, TWIST1, MYBL2, RARA, CREBBP, ZXDC, PRPF4, NOTCH1, NFYC, RUNX2, CDK6, GATA4, ZNF384, DAXX, PBX4, ARNT, NRF1, ATF2, ZNF48, SMAD4, ZEB2, PBX3, ZNF10, SUPT5H, FOS, CDK8, SMARCB1, HMGXB4, MED1, TGIF2, SP2, TEAD3, ZEB1, CEBPD, MYB, PML, U2AF1, ZMYM3, PIAS1, ZNF3, NR1H2, SUPT16H, SETDB1, MBD1, RBM22, MAFK, NIPBL, SP1, GSPT2, HNF4A, BCL11A, USF1, ARID2, IKZF5, ARID1A, REST, RBM25, ATF7, ZHX1, ASH2L, CTBP2, PHIP, BCOR, MBD2, FOXP1, AATF, SMC3, NCOR2, STAG1, MLLT1, ETV4, SKI, TRP47, PPARG, FOXA2, AGO1, CREM, CHD2, PAF1, SS18, ZNF44, MIER2, E2F8, WT1, MAFF, MEIS1, FOXF1, ZBTB33, MEF2C, TCF7, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, FOXO3, ZKSCAN1, MPHOSPH8, NEUROD1, JUNB, BRCA1, SP140, TCF4, HIF1A, MCM3, OTX2, GATA3, TAL1, MAX, NRIP1, ZNF143, AGO2, GATA1, CBX2, KLF4, CEBPG, NCOA3, NR2F2, NEUROG2, NR2F1, KDM5B, TCF7L2, TP53, ZNF687, ZBTB6, RUVBL1, ZNF334, NFKB1, MYOD1, EGR2, PHOX2B, PHF5A, BRD2, ELF3, KAT8, BHLHE40, AR, ARID4B, NFKBIZ, ZNF579, ZBTB40, RXR, YAP1, EGLN2, EGR1, ZBTB26, NCOR1, NOTCH3, JUND, BRD4, HSF1, SCRT1, CUX1, MAZ, SMAD4.1D12, ZNF24, ADNP, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): ERG,PSMG1,SH3BGR,BRWD1,KCNJ6,ETS2,B3GALT5,LCA5L,HMGN1,GET1,GET1-SH3BGR

Function elements

Human SNPs: .

Number of somatic mutations (coding): 38

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene: ENSG00000157542, ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000185658, ENSG00000205581, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000185437, ENSG00000183778,

eachgene

Deatailed information for cohesin site CDBP00419299