- Basic information
- CohesinDB ID: CDBP00419301
- Locus: chr21-38830669-38833619
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR760NPX, ENCSR000EGW, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE93080, ENCSR000DZP, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE206145-NatGen2015, GSE120943, GSE138105, ENCSR199XBQ, ENCSR703TNG, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR620NWG, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, ENCSR807WAC, ENCSR495WGO, ENCSR981FDC, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE73207
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Cell type: MDM, GM2610, SLK, OCI-AML-3, Liver, HuCC-T1, H9-hESC, RPE, HMEC, Fibroblast, HeLa-S3, IMR-90, K-562, HFFc6, DKO, H1-hESC, Monocytes, TF-1, GM12878, GM12891, SK-N-SH, THP-1, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, A-549, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 39% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.644
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 40%,
"7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, TEAD1, E2F5, LMO2, OCA2, HDAC8, E4F1, SOX5, PYGO2, DEK, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, POU5F1, CTBP1, DUX4, STAT1, SAP130, ERG, NFKB2, SMARCA4, FOXK2, ZNF197, ZNF398, RCOR1, DACH1, NFRKB, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, EP400, RUNX1, HDAC1, CEBPA, SP5, TRIM22, SMARCC1, PRDM10, ZXDC, ZBTB2, ELK1, ZBTB10, ATF2, FOXM1, FOXJ2, SMARCB1, ZNF584, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, IKZF5, ARID2, RBM25, AFF1, ELL2, NFATC3, CBFA2T2, MEF2B, CBX3, CREM, SS18, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, TCF4, ZFP36, SPIB, PLAG1, KLF4, ZKSCAN8, MED, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, ILF3, ADNP, ZNF316, FOSL1, XBP1, HNF1A, PBX2, TSC22D4, ATF3, THRB, ZFP64, RUNX3, DPF1, TP63, MITF, BACH2, JMJD1C, INTS11, MAF, SNAI2, KLF10, CTCF, JUN, L3MBTL4, LMO1, MNT, DPF2, IRF4, DDX20, ZNF350, RBPJ, TFAP2C, MLX, MTA2, ZNF317, ZBTB48, NONO, SRF, NBN, CHD4, HOMEZ, RXRA, NKX3-1, MIER3, TEAD2, LEF1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, GRHL2, SSRP1, SMARCA5, NFIL3, THAP11, LDB1, SOX13, AFF4, ARNT, BACH1, DAXX, NFIB, ZNF48, ZEB2, HMBOX1, ETV6, HMGXB4, TEAD3, DIDO1, USF1, SP1, BCL11A, ATF7, ASH2L, SMC3, STAG1, MLLT1, MTA3, EBF1, MEIS1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, GATA3, TAL1, NRIP1, ZNF143, MTA1, TP53, ZNF334, NFKB1, PHF5A, KAT8, TBX21, EGR1, RNF2, BRD4, JUND, CUX1, SMAD4.1D12, IRF9, PGR, PATZ1, UBTF, TFAP4, SIN3B, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, KLF1, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ELK4, ERG2, SP4, TBP, HNF4G, HOXC5, SMARCC2, ETS1, MYC, ARID1B, ZNF24, NKX2-1, GABPA, STAT3, IKZF1, GFI1, EZH2, ZNF652, SPI1, HDAC2, INTS13, NCOA2, ZNF554, ETV5, GTF2A2, BCL6, SIN3A, ERG3, MYBL2, CREBBP, RARA, NFYC, HMGB2, SMAD4, CDK8, ZMYM3, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, ILK, PTTG1, PPARG, GTF2B, TCF7, ZNF318, RELA, MGA, MAX, ZNF592, GFI1B, NEUROG2, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, ZBTB16, ZNF324, ZNF395, AHR, DMAP1, FOSL2, HMG20A, MEIS2, SUZ12, RBFOX2, LYL1, NFIC, PRDM1, MECOM, HDAC3, CDX2, TRIM28, RCOR2, MLL, USF2, TCF12, EP300, GATA6, CREB3, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, MYCN, RUNX1T1, ID3, HINFP, MLLT3, GATAD1, ARID3A, ASCL1, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF750, HES1, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, ZNF766, MYF5, ATF1, PTBP1, SMC1A, CBX1, MAFG, ZFX, SMAD3, IRF2, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, PBX4, NR2C1, FOS, MED1, CEBPD, MYB, VEZF1, ZNF3, L3MBTL2, NIPBL, ZBTB7A, PHIP, TCF3, SKI, FOXA2, MIER2, ZBTB33, CDK9, ZNF589, YY1, HIF1A, BHLHE22, OTX2, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF83, ZNF512, BHLHE40, NFKBIZ, PTRF, TAF1, ZBTB40, ZBTB42, CLOCK, MAZ, MEF2D, BRCA1
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: Schizophrenia
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops