- Basic information
- CohesinDB ID: CDBP00419304
- Locus: chr21-38837705-38842238
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Data sourse: GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, ENCSR330ELC, GSE108869, GSE165895, ENCSR000EFJ, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE135093, GSE120943, GSE206145-NatGen2015, GSE138105, ENCSR199XBQ, ENCSR703TNG, ENCSR895JMI, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, ENCSR000ECS
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Cell type: SLK, HuCC-T1, RPE, HMEC, Fibroblast, HeLa-S3, IMR-90, K-562, HFFc6, Monocytes, SK-N-SH, RT-112, Macrophage, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 29% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.789
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 46%,
"7_Enh": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SMARCA2, HMG20A, SOX2, MEIS2, XBP1, FOXA1, PBX2, RXRB, MLL4, SMAD1-5, ATF3, NFIC, SETX, THAP1, CHD7, PRDM1, ATF4, CBFB, SMARCE1, ZSCAN4, TP63, MITF, ZNF736, MAF, TEAD1, ELF1, TRIM28, KLF6, NFE2L2, LMO2, ESR1, MLL, TP73, OCA2, HDAC8, USF2, JUN, TCF12, CTCF, EP300, E4F1, KLF1, SOX5, PYGO2, DPF2, E2F6, TRIM24, RFX5, CREB3, SOX6, DEK, DDX20, E2F1, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, TFAP2C, EED, POU2F2, CHD8, MYCN, SRC, RUNX1T1, CTBP1, ZBTB48, DUX4, STAT1, ZSCAN5A, GATAD1, SAP130, NBN, ARID3A, ERG2, TBP, ERG, HOXC5, ETS1, MYC, EZH1, SMARCA4, RFX1, ARID1B, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, ZNF614, RCOR1, MIER3, NR2F6, NFRKB, ZNF639, VDR, NR3C1, ESRRA, CEBPB, NFE2, KMT2A, CREB1, EPAS1, TBL1XR1, EBF3, GABPB1, ZNF436, ZHX2, SPI1, EHF, IRF1, HDAC2, GATA2, ZNF644, MXD3, FLI1, NR2C2, RELB, EP400, ATF1, ETV5, RUNX1, SMC1A, BCL6, HDAC1, LDB1, CEBPA, MAFG, SOX13, ZFX, ZNF335, SIN3A, EZH2phosphoT487, SMAD3, SMARCC1, MEF2A, RARA, CREBBP, ZNF384, RUNX2, CDK6, GATA4, ZNF184, ARNT, NRF1, DAXX, PBX4, BACH1, ZNF48, ATF2, ZEB2, SMAD4, ZBTB10, CBFA2T3, PBX3, FOXM1, SMARCB1, FOS, CDK8, NR2C1, MED1, TEAD3, DIDO1, CEBPD, ZEB1, ZMYM3, NR1H2, C11orf30, L3MBTL2, SETDB1, HIF2A, ZNF22, USF1, BCL11A, SP1, MAFK, HNF4A, NR4A1, REST, ZBTB7A, ATF7, ZHX1, PHIP, FOXP1, SMC3, STAG1, STAG2, MLLT1, SKI, PPARG, FOXA2, MTA3, CREM, MEIS1, BRF2, SS18, ZNF316, ZNF692, GTF2B, WT1, MAFF, ESR2, ZNF662, ZBTB33, MEF2C, ZNF580, ZNF318, KDM1A, ZNF589, RELA, YY1, TARDBP, JUNB, SP140, ZFP36, HIF1A, GATA3, MGA, TAL1, MAX, NRIP1, GATA1, ZNF143, CBX2, PLAG1, CEBPG, ZNF592, KLF4, GFI1B, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, NEUROG2, TP53, PKNOX1, NFKB1, MYOD1, ELF3, BRD2, KAT8, ARID4B, AR, BHLHE40, PTRF, TAF1, ZBTB40, YAP1, PAX3-FOXO1, EGLN2, ZBTB26, RNF2, JUND, BRD4, ILF3, MAZ, IRF9, MEF2D, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 23
- Related genes and loops