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Basic information

CohesinDB ID: CDBP00419307

Locus: chr21-38849471-38854263

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR000BLY, ENCSR150EFU, GSE111537, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE135093, GSE206145-NatGen2015, GSE112028, GSE138105, ENCSR199XBQ, ENCSR703TNG, GSE94872, ENCSR895JMI, ENCSR193NSH, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, GSE206145, GSE85526, ENCSR247LSH, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE38395, ENCSR944ZCT, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE126755, ENCSR000ECS, GSE73207

Cell type: SLK, OCI-AML-3, Liver, HuCC-T1, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, hLCL, IMR-90, K-562, HFFc6, DKO, TF-1, SK-N-SH, RT-112, HeLa-Tet-On, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HUVEC, HCAEC, HeLa, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 29% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.689

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 42%, "7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, HMG20A, MEIS2, HNF1A, FOXA1, HLF, RXRB, PBX2, KDM3A, TFAP4, HDGF, NFIC, PRDM1, ATF4, MXD4, SMARCE1, PAX5, BACH2, JMJD1C, TEAD1, TRIM28, ELF1, E2F5, ETV1, RCOR2, HDAC8, TCF12, EP300, E4F1, MNT, SOX5, PYGO2, DPF2, E2F6, TRIM24, CREB3, SOX6, ZNF674, TEAD4, FOXA3, ZNF175, GATAD2A, EHMT2, MLX, RBPJ, POU5F1, HHEX, CTBP1, MTA2, STAT1, GATAD1, SAP130, NBN, ARID3A, TBP, ERG, MYC, SMARCA4, HOMEZ, RAD21, ARID1B, GRHL3, FOXP2, RXRA, FOXK2, GABPA, APC, ZNF614, XRCC5, IKZF1, MIER3, NFE2, NR2F6, NFRKB, ZNF639, RCOR1, LEF1, CEBPB, TBL1XR1, EZH2, GABPB1, ZHX2, SPI1, MIXL1, TFE3, IRF1, HDAC2, GATA2, ZNF644, MXD3, SIX2, ZSCAN29, ZGPAT, NFIL3, NCOA2, ETV5, RUNX1, THAP11, MAFG, BCL6, CEBPA, HDAC1, CBX1, LDB1, SOX13, ZFX, SIRT6, SP5, MYBL2, RARA, BRD9, GATA4, OSR2, ZNF184, ARNT, BACH1, TFDP1, NRF1, ZNF48, SMAD4, CBFA2T3, FOXM1, NR2C1, HMGXB4, CDK8, MED1, ZNF584, GMEB1, TEAD3, DIDO1, CEBPD, MYB, TAF7, C11orf30, L3MBTL2, NCOA1, SETDB1, STAT5A, USF1, SP1, BCL11A, HNF4A, NR4A1, IKZF5, REST, ZBTB7A, AFF1, FOXP1, SMC3, ILK, STAG1, ETV4, SKI, CBFA2T2, KLF13, PPARG, FOXA2, CBX3, CREM, WT1, TCF7, ZNF580, KDM1A, ZNF589, RELA, YY1, NEUROD1, OTX2, MGA, TAL1, MAX, GATA1, CEBPG, ZNF592, GFI1B, NR2F2, NR2F1, ELF3, PHF5A, KAT8, TBX21, NFKBIZ, ARID4B, BHLHE40, AR, ZBTB40, EGR1, ZBTB26, NCOR1, RNF2, BRD4, JUND, MYNN, MAZ, ZNF395

Target gene symbol (double-evidenced CRMs): LCA5L,PCP4,GET1,PSMG1,B3GALT5,ERG,GET1-SH3BGR

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 23

Related genes and loops

Related gene: ENSG00000157554, ENSG00000183527, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000183778, ENSG00000183036,

eachgene

Deatailed information for cohesin site CDBP00419307