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Basic information

CohesinDB ID: CDBP00419308

Locus: chr21-38856453-38857719

Data sourse: ENCSR167MTG, GSE206145-GSE177045, GSE67783, ENCSR000BKV, GSE72082, GSE86191, GSE111913, ENCSR879KXD, ENCSR000BLS, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE112028, GSE68388, GSE25021, GSE108869, ENCSR000ECS

Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hep-G2, HeLa-S3, RT-112, K-562, HeLa-Tet-On, HSPC, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 50%, "7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, HMG20A, MEIS2, XBP1, TBL1X, PATZ1, FOXA1, HLF, PBX2, SMAD1-5, MLL4, SFMBT1, RXRB, TFAP4, KDM3A, UBTF, HDGF, LYL1, ATF3, NFIC, HMGB2, CHD7, PRDM1, ZNF444, ATF4, MXD4, MECOM, SMARCE1, PAX5, TP63, ZNF736, BACH2, CDX2, ZNF629, JMJD1C, MYOG, TEAD1, TRIM28, KLF6, SNAI2, NFE2L2, ZNF217, ESR1, RCOR2, TP73, USF2, JUN, TCF12, CTCF, EP300, E4F1, MNT, SOX9, SOX5, DPF2, SOX4, E2F6, DMAP1, TRIM24, RFX5, SOX6, DEK, E2F1, SMC1, RFX3, TEAD4, FOXA3, GATAD2A, PDX1, RBPJ, GTF2F1, TFAP2C, GLIS1, MLX, ZNF263, POU5F1, TOP2A, MYCN, CTBP1, MTA2, ZSCAN21, ZBTB48, ZSCAN5A, DUX4, GATAD1, SAP130, ARID3A, TBP, ERG, HOXC5, PBX1, ASCL1, SMARCC2, ETS1, MYC, SMARCA4, ARID1B, RAD21, HOMEZ, FOXP2, GRHL3, RXRA, NKX2-1, PROX1, GABPA, STAT3, ZNF614, XRCC5, UBN1, NKX3-1, IKZF1, NFE2, RCOR1, MIER3, NFRKB, ZNF639, VDR, NR2F6, CEBPB, NR3C1, ZNF750, ESRRA, KMT2A, CREB1, CCAR2, EZH2, KLF8, GRHL2, EBF3, GABPB1, ZHX2, SPI1, TFE3, EHF, KLF17, HDAC2, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, ZGPAT, MXI1, SMARCA5, ZNF490, EP400, NFIL3, NCOA2, MYF5, PTBP1, RUNX1, THAP11, CTNNB1, MAFG, CBX1, HDAC1, CEBPA, NKX2-2, SMC1A, AFF4, ZFX, SOX13, EZH2phosphoT487, SIN3A, SMAD3, LDB1, TET2, SMARCC1, TWIST1, CREBBP, RARA, ZXDC, BRD9, RUNX2, CDK6, SMAD2, OSR2, ZNF184, CREM, PBX4, NRF1, ARNT, DAXX, ZNF48, PRDM9, ZEB2, SMAD4, ATF2, CBFA2T3, PBX3, ZNF10, FOS, CDK8, SMARCB1, HMGXB4, FOXM1, MED1, MAFB, CHD1, ZEB1, TEAD3, CEBPD, MYB, SCRT2, ZMYM3, TERF1, ZNF3, NR1H2, C11orf30, L3MBTL2, MAFK, NIPBL, SP1, BCL11A, SMAD2-3, IKZF5, REST, ARID1A, RBM25, ATF7, ZHX1, PHIP, BCOR, TCF3, AFF1, MBD2, FOXP1, ZNF623, SMC3, ELL2, NCOR2, MLLT1, STAG1, STAG2, SKI, CBFA2T2, ZNF316, CBX3, FOXA2, MTA3, CHD2, PPARG, EBF1, ZNF600, ZNF692, GTF2B, MAFF, WT1, PAF1, ESR2, ZNF662, ZBTB33, ZNF580, ZNF318, KDM1A, YY1, RELA, CREB3L1, TARDBP, JUNB, NEUROD1, BRCA1, SP140, TCF4, HIF1A, SKIL, ZIC2, BHLHE22, GATA3, ZFP36, BATF, TAL1, MAX, NRIP1, GATA1, ZNF143, MTA1, HAND2, BCL6, CEBPG, ZNF592, SP7, GFI1B, NR2F2, ZNF512, TCF7L2, NR2F1, KDM5B, NEUROG2, TP53, PKNOX1, ZNF687, MED, NFKB1, MYOD1, ZSCAN22, ELF3, BRD2, KAT8, BHLHE40, AR, NFKBIZ, ARID4B, ZBTB40, EGLN2, ZNF366, ZBTB42, ZBTB26, NCOR1, HSF1, JUND, BRD4, SCRT1, MAZ, ZSCAN23, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): B3GALT5,GET1-SH3BGR,LCA5L,GET1,PCP4,PSMG1,ERG

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000157554, ENSG00000183527, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000183778, ENSG00000183036,

eachgene

Deatailed information for cohesin site CDBP00419308