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Basic information

CohesinDB ID: CDBP00419315

Locus: chr21-38869262-38870389

Data sourse: ENCSR230ZWH, GSE72082, GSE25021, ENCSR917QNE, ENCSR000EFJ, GSE122299, GSE138405, GSE206145-NatGen2015, GSE135093, GSE120943, GSE130135, ENCSR703TNG, GSE98367, GSE206145, ENCSR000BTQ, GSE129526, ENCSR000HPG, ENCSR054FKH, ENCSR000EDE, GSE126990, GSE126755

Cell type: MCF-7, Hela-Kyoto, Fibroblast, HCT-116, HEK293T, Hep-G2, Monocytes, HeLa-S3, IMR-90, Liver, Neutrophil, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 7% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 74%, "14_ReprPCWk": 11%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, SMC1A, CHD8, CEBPA, ZSCAN5D, BCL6, XBP1, STAT1, ERG, KDM1A, RELA, ZNF384, PBX1, NEUROD1, MYC, ZNF184, TCF4, GRHL3, OTX2, ATF2, TAL1, IKZF1, NFE2, HAND2, PLAG1, NR3C1, CEBPB, JMJD1C, NCOA3, TRIM28, KMT2A, MYB, LMO2, ESR1, ZNF334, TCF12, SPI1, SP1, BCL11A, NR4A1, PAX3-FOXO1, PAX8, FLI1, TCF3

Target gene symbol (double-evidenced CRMs): GET1,ERG,LCA5L,B3GALT5,PCP4,GET1-SH3BGR,PSMG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157554, ENSG00000183527, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000183778, ENSG00000183036,

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Deatailed information for cohesin site CDBP00419315