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Basic information

CohesinDB ID: CDBP00419318

Locus: chr21-38874324-38875151

Data sourse: GSE67783, GSE86191, GSE98367, GSE206145, GSE206145-NatGen2015, GSE126755

Cell type: RPE, Fibroblast, HCT-116, Neutrophil, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 78%, "14_ReprPCWk": 9%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RELA, NOTCH1, OGG1, JMJD1C, PPARG, BRD1, TRIM28, CEBPA, CEBPB, ZFX, ESR1, WT1, ZSCAN5A, DUX4, SOX11, ZBTB48, MAZ, CTCF, SPI1, NFE2

Target gene symbol (double-evidenced CRMs): GET1,GET1-SH3BGR,LCA5L,ERG,PSMG1,PCP4,B3GALT5

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 7

Related genes and loops

Related gene: ENSG00000157554, ENSG00000183527, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000183778, ENSG00000183036,

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Deatailed information for cohesin site CDBP00419318