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Basic information

CohesinDB ID: CDBP00419326

Locus: chr21-38897435-38899519

Data sourse: ENCSR230ZWH, GSE138405, GSE25021, GSE206145, GSE62063, GSE120943, ENCSR000EDE, GSE111537, GSE126990, ENCSR917QNE

Cell type: MCF-7, RPE, Hela-Kyoto, Monocytes, HeLa-S3, Liver, OCI-AML-3, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: NIPBL,Rad21,SMC1,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 70%, "7_Enh": 12%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, ZNF660, MEIS2, FOXA1, PBX2, ZFHX2, ATF3, ZNF362, ZNF189, CDX2, ZNF629, JMJD1C, TRIM28, ESR1, USF2, JUN, BAF155, EP300, IRF4, TRIM24, PDX1, RBPJ, NANOG, ZSCAN21, ZBTB17, DUX4, STAT1, ELK4, ERG2, ERG, ASCL1, MYC, RAD21, RXRA, NKX2-1, STAT3, NKX3-1, RCOR1, NR3C1, CEBPB, KMT2A, CREB1, KLF8, SPI1, EHF, GATA2, INTS13, ZNF644, FLI1, RUNX1, CEBPA, NKX2-2, SMAD3, ZBTB12, ERG3, PRDM10, ZNF384, NOTCH1, CDK6, ZNF184, PBX4, ATF2, PRDM9, ETV6, FOS, CDK8, MED1, MYB, SCRT2, PIAS1, SP1, BCL11A, HNF4A, ARID1A, ATF7, PHIP, PRDM6, MEF2B, PPARG, FOXA2, EBF1, ZNF600, ZNF692, ZSCAN16, MEF2C, ZNF823, CDK9, HOXB13, ZKSCAN1, YY1, RELA, TARDBP, JUNB, TCF4, HIF1A, GATA3, MAX, TLE3, CEBPG, SP7, PKNOX1, NFKB1, MYOD1, BRD2, AR, HSF1, NCOR1, BRD4, JUND, SCRT1, CLOCK

Target gene symbol (double-evidenced CRMs): ERG,PSMG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000157554, ENSG00000183527,

eachgene

Deatailed information for cohesin site CDBP00419326