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Basic information

CohesinDB ID: CDBP00419327

Locus: chr21-38902877-38915813

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, GSE132649, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE165895, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE94872, ENCSR895JMI, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR879KXD, GSE206145, GSE85526, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE126755, ENCSR000ECS

Cell type: Liver, GP5d, HuCC-T1, H9-hESC, RPE, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, DKO, H1-hESC, Monocytes, MB157, SK-N-SH, RT-112, HeLa-Tet-On, Macrophage, MCF-7, T-47D, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, HeLa, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 42% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.611

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 33%, "5_TxWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, HMG20A, SOX2, MEIS2, FOXA1, PBX2, ATF3, CBFB, PAX5, TP63, ZSCAN4, MAF, KLF5, TRIM28, ZNF26, SNAI2, ESR1, TP73, CTCF, JUN, E2F1, SMC1, GLIS1, CDK9-HEXIM1, ZNF425, POU2F2, ZSCAN5D, MYCN, CHD8, ID3, ZBTB17, ZBTB48, GATAD1, HNF4G, ERG, ONECUT1, MYC, RAD21, GRHL3, RXRA, GABPA, STAT3, NR2F6, NR3C1, CEBPB, ZNF750, GRHL2, HES1, EHF, GATA2, RUNX1, SMC1A, CEBPA, SOX13, ZFX, SMAD3, CREBBP, RARA, RUNX2, ARNT, NRF1, SMAD4, ZEB2, FOS, CHD1, MED1, TEAD3, C11orf30, SETDB1, TBX5, MAFK, SP1, HNF4A, NKX2-5, REST, STAG2, STAG1, MLLT1, PPARG, FOXA2, WT1, MAFF, ZBTB33, ZKSCAN1, YY1, RELA, NEUROD1, JUNB, SP140, ZIC2, HIF1A, ZFP36, OTX2, GATA3, MAX, ZNF143, KLF4, SP7, NCOA3, NR2F2, NR2F1, KDM5B, TP53, ZNF334, NFKB1, PAX3-FOXO1, AR, TAF1, EGLN2, ZBTB42, EGR1, ZBTB26, BRD4, JUND, MAZ, BRCA1, ZNF316

Target gene symbol (double-evidenced CRMs): GET1-SH3BGR,ERG,GET1,ETS2

Function elements

Human SNPs: Periodontitis_(Mean_PAL)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 68

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000285815, ENSG00000182093,

eachgene

Deatailed information for cohesin site CDBP00419327