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Basic information

CohesinDB ID: CDBP00419329

Locus: chr21-38918470-38919889

Data sourse: ENCSR167MTG, ENCSR230ZWH, GSE72082, GSE98367, ENCSR000BSB, GSE138405, GSE129526, GSE25021, GSE76893, ENCSR000BLS, ENCSR054FKH, GSE120943, GSE126990, ENCSR000ECS, ENCSR917QNE

Cell type: Hela-Kyoto, HCT-116, Monocytes, Hep-G2, HeLa-S3, Liver, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 33%, "5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, PAX5, SFPQ, TEAD1, ZNF121, LMO2, OCA2, ZNF23, E4F1, ZNF157, SOX5, PYGO2, PAX8, ZNF407, ZNF211, DEK, E2F4, ZNF410, ZNF528, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, TOP2A, CTBP1, DUX4, STAT1, ZNF488, SAP130, ZNF485, ERG, ZBTB21, SMARCA4, RFX1, DNMT1, FOXK2, ZNF8, UBN1, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, ZNF785, RUNX1, CEBPA, NKX2-2, ZNF707, HDAC1, REPIN1, TET2, SP5, MCM2, TRIM22, SMARCC1, PRDM10, ZXDC, ZBTB2, ELK1, ZBTB10, SNIP1, ATF2, FOXM1, SP2, SMARCB1, PIAS1, NR1H2, IKZF5, ARID2, OVOL3, RBM25, MBD2, ELL2, ETV4, NFATC3, ZSCAN18, CBFA2T2, MEF2B, ZNF207, CREM, CHD2, NFATC1, SS18, PAF1, ZSCAN16, WT1, JUNB, NEUROD1, MCM3, ZFP36, TCF4, ZNF311, BATF, MAF1, ZSCAN26, PLAG1, KLF4, BCL11B, ZFP69B, ZNF544, IRF5, BCL6B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ADNP, ZNF316, FOSL1, SMARCA2, XBP1, HNF1A, PBX2, HNRNPK, ATF3, THRB, ZFP64, CBFB, ZNF273, TP63, ZSCAN4, MITF, CDC5L, ZNF467, JMJD1C, ELF1, RBM39, SNAI2, KLF10, JUN, CTCF, TAF3, L3MBTL4, MNT, ZBTB20, LMO1, DPF2, RYBP, MED12, ZNF280A, PDX1, TFAP2C, RBPJ, PLRG1, YBX1, MLX, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, PHB2, CHD4, ONECUT1, TRIP13, KDM4A, HOMEZ, ZNF2, FOXP2, TSHZ1, RXRA, NKX3-1, LEF1, TERF2, MIER3, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, KLF8, ARHGAP35, GRHL2, SSRP1, ZNF146, SMARCA5, NFIL3, THAP11, CTNNB1, ZBTB24, EZH2phosphoT487, LDB1, AFF4, SOX13, ZNF747, ZNF792, ZNF18, SP3, NFIB, DAXX, ARNT, ZNF48, ZEB2, ETV6, MAFB, PBX3, HMGXB4, TEAD3, ZXDB, ZNF670, ZNF680, U2AF1, KLF9, TBX5, USF1, SP1, TFAP2A, BCL11A, NKX2-5, ATF7, ASH2L, ZNF548, CTBP2, GLIS2, SMC3, STAG1, STAG2, MLLT1, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KDM1A, ZNF266, BRG1, ZNF155, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, ZNF141, TP53, ZNF645, NFKB1, ZNF140, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, ZFP41, EGR1, RNF2, BRD4, JUND, CUX1, ZSCAN23, IRF9, TBX2, PGR, FANCL, SOX2, PATZ1, TFAP4, SIN3B, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, RLF, KLF6, MCM7, NFE2L2, ZNF217, ESR1, SAP30, TP73, KLF1, SOX9, ZNF260, E2F6, TRIM24, RFX5, PRKDC, ZNF92, GTF2F1, GLIS1, POU2F2, KDM4C, ZBTB1, ZSCAN5A, ERG2, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, PHF21A, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, YBX3, EZH2, ZNF652, PHF8, SPI1, ZNF202, HDAC2, INTS13, GATAD2B, ATM, NCOA2, ZNF76, SALL2, ETV5, BCL6, SIN3A, ERG3, NFXL1, MEF2A, MYBL2, CREBBP, RARA, ZNF384, NFYC, TAF15, ZNF169, ZNF280C, ZNF781, HMGB2, ZNF518A, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF816, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF662, TCF7, YY2, FOXO3, RELA, TARDBP, MAX, ZNF223, ZNF592, TCF7L2, NR2F1, KDM5B, ZNF791, PKNOX1, MYOD1, AR, ZNF324, RBAK, HEXIM1, ZNF280D, AHR, FOSL2, MBD3, DMAP1, ZNF391, HMG20A, SUZ12, RBFOX2, ZFHX2, ZNF274, INSM2, NFIC, ZNF90, CTCFL, ZBTB5, PRDM1, KLF14, CDX2, KLF5, BCLAF1, TRIM28, ZNF26, RCOR2, HNF1B, USF2, MBD4, TCF12, EP300, BAF155, GATA6, ZNF302, PRDM4, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, ATRX, CHD8, BRD1, MYCN, SRC, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, ZNF300, AEBP2, ZNF585B, ASCL1, MIER1, MCM5, EOMES, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, TRPS1, HES1, TFE3, EHF, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, CBX1, SMC1A, SIRT6, ZNF335, ZFX, SMAD3, PCBP2, TWIST1, ZNF701, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, NRF1, FOS, CHD1, SUPT5H, MED1, CEBPD, MYB, SCRT2, ZNF3, KLF16, NIPBL, PHF20, ZBTB7A, PHIP, TCF3, SALL1, SKI, NCOA4, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZNF493, ZBTB33, CDK9, HOXB13, YY1, ZNF148, BRCA1, SP140, HIF1A, OTX2, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, ZNF837, BHLHE40, NFKBIZ, TAF1, ZBTB40, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): ERG,GET1-SH3BGR,ETS2,GET1

Function elements

Human SNPs: Inflammatory_skin_disease

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000285815, ENSG00000182093,

eachgene

Deatailed information for cohesin site CDBP00419329