- Basic information
- CohesinDB ID: CDBP00419341
- Locus: chr21-38947518-38949339
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Data sourse: GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT
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Cell type: RPE, Fibroblast, HCT-116, RT-112, K-562
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: Mau2,SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 48%,
"14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SOX2, NME2, HNF1A, FOXA1, HLF, SUZ12, PBX2, MLL4, ZFHX2, TFAP4, ATF3, NFIC, CHD7, IKZF3, ZNF189, TP63, HDAC3, CDX2, JMJD1C, KLF5, TEAD1, TRIM28, ETV1, KLF6, NFE2L2, ESR1, OCA2, HNF1B, MLL, ZNF561, CTCF, TCF12, JUN, EP300, BAF155, SOX9, GATA6, E2F6, TRIM24, E2F1, SMC1, ZNF350, TEAD4, KMT2B, TFAP2C, EED, GLIS1, POU2F2, CHD8, NANOG, ZSCAN5D, MYCN, POU5F1, RUNX1T1, ZNF263, BRD3, TOP2A, ERF, ZNF778, ZBTB48, ZSCAN5A, DUX4, ZNF485, SAP130, ERG2, SP4, HNF4G, ERG, HOXC5, OGG1, ZNF341, ZBTB8A, MYC, EOMES, TSHZ1, RAD21, FOXP2, GRHL3, RXRA, NKX2-1, PROX1, GABPA, STAT3, NKX3-1, RCOR1, NFE2, HNRNPH1, NR2F6, VDR, NR3C1, CEBPB, CREB1, EZH2, BMPR1A, FEZF1, ZHX2, SPI1, EHF, KLF17, IRF1, HDAC2, GATA2, SIX2, FLI1, HCFC1R1, NFIL3, NFYB, ATF1, RUNX1, CTNNB1, SMC1A, MAFG, HDAC1, EZH2phosphoT487, NKX2-2, CEBPA, SIN3A, ZFX, ZNF534, POU4F2, SMAD3, ZFP3, TET2, ERG3, ZNF549, PRDM10, CREBBP, ZNF35, ZNF384, RARA, TAF15, RUNX2, ZSCAN30, GATA4, OSR2, ARNT, BACH1, PBX4, ATF2, ZNF48, ZNF518A, PBX3, CBFA2T3, SMARCB1, CDK8, CHD1, FOS, MED1, TEAD3, ZXDB, CEBPD, MYB, PIAS1, VEZF1, NR1H2, NCOA1, L3MBTL2, ZNF41, SETDB1, KLF16, MAFK, SP1, USF1, GSPT2, BCL11A, NIPBL, HNF4A, REST, ARID1A, ATF7, ASH2L, CTBP2, PHIP, BCOR, FOXP1, PRDM6, AATF, SMC3, NCOR2, STAG2, STAG1, MLLT1, NFATC3, PAX7, TRP47, CBFA2T2, ZNF316, TBL1X, FOXA2, ZNF207, CHD2, CREM, SS18, PPARG, WT1, ZNF30, FOXF1, ZNF574, HOXB13, ZKSCAN1, ZNF580, KDM1A, YY1, RELA, JUNB, BRG1, ZNF610, SP140, ZIC2, HIF1A, TCF4, GATA3, TAL1, MAX, ZNF143, GATA1, PLAG1, TLE3, KLF4, CEBPG, SP7, NCOA3, GFI1B, NR2F2, NEUROG2, TCF7L2, TP53, PKNOX1, NFKB1, BRD2, T, ELF3, ZNF843, ZFP28, AR, RXR, ZBTB42, HEXIM1, ZBTB26, HSF1, NCOR1, BRD4, JUND, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): GET1-SH3BGR,GET1,ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000157554,
ENSG00000285815,
ENSG00000182093,
- Related loop:
chr21:38525000-38550000~~chr21:38950000-38975000,
chr21:38575000-38600000~~chr21:38925000-38950000,
chr21:38800000-38825000~~chr21:38950000-38975000,
chr21:38925000-38950000~~chr21:39025000-39050000,
chr21:38925000-38950000~~chr21:39050000-39075000,
chr21:38925000-38950000~~chr21:39100000-39125000,
chr21:38925000-38950000~~chr21:39125000-39150000,
chr21:38925000-38950000~~chr21:39375000-39400000,
chr21:38950000-38975000~~chr21:39050000-39075000,
chr21:38950000-38975000~~chr21:39100000-39125000,
chr21:38950000-38975000~~chr21:39125000-39150000,