- Basic information
- CohesinDB ID: CDBP00419347
- Locus: chr21-38964963-38966859
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE105028, GSE131606, GSE25021, ENCSR000EDW, GSE115602, ENCSR917QNE, GSE165895, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE135093, ENCSR703TNG, ENCSR000EEG, ENCSR338DUC, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR635OSG, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Hela-Kyoto, Hep-G2, A-549, DKO, RT-112, IMR-90, HSPC, K-562, Liver, HFFc6, HuCC-T1, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 16% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.811
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 50%,
"7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, LCORL, SOX2, XBP1, FOXA1, HLF, RBFOX2, RXRB, PBX2, KDM3A, TFAP4, THRB, NFIC, ATF3, ZFP64, BMI1, ZBTB44, ZNF444, ATF4, MXD4, DPF1, SMARCE1, MITF, KLF5, TEAD1, ELF1, TRIM28, KLF6, SNAI2, NFE2L2, RBM39, RCOR2, ESR1, ZNF217, USF2, ZNF561, ZFP91, CTCF, JUN, EP300, E4F1, MNT, SOX5, PAX8, DPF2, DMAP1, E2F6, E2F4, RAD51, PRKDC, E2F1, ZNF350, RFX3, TEAD4, FOXA3, ZNF175, GATAD2A, EHMT2, MLX, RBPJ, TFAP2C, GTF2F1, PDX1, CHD8, ZSCAN5D, BRD3, MYCN, ZNF263, ID3, POU5F1, CTBP1, ZSCAN21, ZBTB17, ZBTB48, NONO, SRF, GATAD1, SAP130, GMEB2, ARID3A, TBP, ERG, ASCL1, ZBTB8A, ETS1, MYC, ONECUT1, SMARCA4, RFX1, HOMEZ, RAD21, FOXP2, RXRA, NKX2-1, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, MIER3, DNMT3B, NR2F6, RCOR1, NR3C1, CEBPB, ESRRA, CREB1, TBL1XR1, GRHL2, ZNF652, GABPB1, PHF8, ZHX2, ELF4, SPI1, TFE3, MIXL1, HBP1, IRF1, HDAC2, GATA2, SSRP1, ZNF644, MXD3, SREBF1, DRAP1, ZGPAT, NR2C2, MXI1, HCFC1, NFIL3, EP400, NFYB, ATF1, ETV5, PTBP1, THAP11, ZNF585A, BCL6, SMC1A, CEBPA, NKX2-2, HDAC1, CBX1, SIN3A, ZFX, SOX13, AFF4, FIP1L1, SMAD3, PCBP2, ZNF770, SP5, SMARCC1, PRDM10, RARA, ZNF384, NFYC, CREBBP, IRF2, ZNF35, RUNX2, GATA4, ZNF184, NFIB, NRF1, ARNT, ZNF48, SMAD4, ZNF518A, ZEB2, NFYA, MAFB, FOS, CDK8, HMGXB4, MED1, TEAD3, PML, CEBPD, SCRT2, SMAD1, ZNF3, NR1H2, L3MBTL2, SETDB1, RBM22, USF1, SP1, TFAP2A, BCL11A, HNF4A, IKZF5, REST, ARID1A, ZBTB7A, RBM25, ATF7, ASH2L, HNRNPLL, PHIP, MBD2, FOXP1, SMC3, ELL2, STAG1, ETV4, SKI, NELFA, CBFA2T2, PPARG, FOXA2, CBX3, EBF1, CREM, ZNF316, MTA3, MIER2, CHD2, WT1, ESR2, MEF2C, TCF7, ZBTB33, CDK9, ZNF580, ZKSCAN1, FOXO3, KDM1A, YY1, RELA, NEUROD1, SP140, ZFP36, HIF1A, GATA3, MGA, TAL1, MAX, NRIP1, ZNF143, MTA1, HAND2, PLAG1, CEBPG, ZNF592, SP7, GFI1B, NR2F2, NCOA3, NEUROG2, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, ZBTB6, MYOD1, BRD2, ELF3, KAT8, PHF5A, BHLHE40, AR, NFKBIZ, ARID4B, ZNF579, TAF1, ZBTB40, EGLN2, ZBTB26, RNF2, BRD4, JUND, SCRT1, CLOCK, ILF3, MAZ, CUX1, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): ETS2,ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops