- Basic information
- CohesinDB ID: CDBP00419349
- Locus: chr21-38968672-38969620
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Data sourse: ENCSR167MTG, ENCSR338DUC, GSE67783, GSE72082, GSE86191, GSE76893, ENCSR000BLS, ENCSR054FKH, GSE130135, GSE111537, GSE25021, ENCSR000EDW, GSE55407
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Cell type: HCT-116, Hep-G2, HEK293T, THP-1, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 69%,
"14_ReprPCWk": 10%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, HMG20A, ZSCAN5C, SOX2, XBP1, FOXA1, RXRB, UBTF, MLL4, ZFHX2, TFAP4, LYL1, ZFP64, CHD7, PRDM1, CBFB, ZNF189, TP63, JMJD1C, MAF, TEAD1, ZNF121, TRIM28, KLF6, RCOR2, ESR1, MLL, OCA2, LMO2, CTCF, JUN, EP300, SOX5, DPF2, PAX8, PRDM4, TRIM24, SOX6, ZNF423, ZNF528, SMC1, TEAD4, FOXA3, KMT2B, GATAD2A, RBPJ, MLX, TFAP2C, GLIS1, POU2F2, CHD8, POU5F1, ZNF317, MTA2, ZBTB48, ZSCAN5A, STAT1, MLLT3, GATAD1, SAP130, ERG2, ERG, ASCL1, OGG1, ZNF341, ETS1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, PROX1, STAT3, ZNF614, XRCC5, IKZF1, GFI1, RCOR1, NFE2, MIER3, VDR, NR2F6, CEBPB, CREB1, FEZF1, ZNF652, GABPB1, SPI1, MIXL1, TFE3, INTS13, GATA2, ZNF644, GATAD2B, MXD3, FLI1, DRAP1, ZGPAT, RELB, NFIL3, ZNF554, ETV5, RUNX1, THAP11, BCL6, SMC1A, HDAC1, CEBPA, ZNF335, ZFX, SOX13, ZNF770, ERG3, SP5, RARA, ZNF35, NOTCH1, ZNF384, RUNX2, OSR2, ARNT, ZNF48, ATF2, SMAD4, HMBOX1, PRDM9, HMGB2, FOS, CDK8, HMGXB4, TEAD3, MYB, SCRT2, STAT5A, BCL11A, IKZF5, ATF7, HNRNPLL, PHIP, FOXP1, SMC3, STAG1, MLLT1, STAG2, SKI, PPARG, FOXA2, MIER2, ZSCAN16, WT1, MEF2C, CDK9, ZNF580, KDM1A, YY1, RELA, SP140, TCF4, ZIC2, TAL1, MAX, GATA1, CEBPG, SP7, GFI1B, NR2F2, NR2F1, TP53, ZNF213, MED, ZSCAN22, MYOD1, EGR2, BRD2, ELF3, KAT8, TBX21, NFKBIZ, BHLHE40, ARID4B, PAX3-FOXO1, AR, ZBTB42, EGR1, HSF1, ZBTB26, BRD4, JUND, SCRT1, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): ETS2,ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 5
- Related genes and loops