- Basic information
- CohesinDB ID: CDBP00419355
- Locus: chr21-38983801-38991057
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Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE25021, ENCSR000EDW, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE143937, GSE165895, GSE67783, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR703TNG, GSE116344, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, GSE206145, ENCSR000EHX, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE73207
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Cell type: MDM, RH4, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, Monocytes, TF-1, SK-N-SH, RT-112, HeLa-Tet-On, THP-1, Macrophage, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, HUVEC, HCAEC, HeLa, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 24% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.622
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 35%,
"5_TxWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, THAP1, ZBTB44, IKZF3, PAX5, TEAD1, ZNF121, E2F5, LMO2, PITX3, HDAC8, ZNF561, ZNF577, ARID5B, E4F1, SOX5, E2F4, DEK, ZNF528, KMT2B, GATAD2A, NANOG, BRD3, ZNF263, TOP2A, POU5F1, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, PAX6, ZBTB8A, EZH1, SMARCA4, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, DACH1, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, NR2C2, RELB, RUNX1, CEBPA, HDAC1, NKX2-2, REPIN1, TET2, TBX3, SP5, SMARCC1, PRDM10, ZNF549, ELK1, ZBTB10, ATF2, FOXM1, SP2, ZNF584, PML, PIAS1, SMAD1, C11orf30, EVI1, MBD1, STAT5A, ARID2, IKZF5, OVOL3, RBM25, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, CBX3, CREM, CHD2, SS18, NFATC1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZNF510, TCF4, ZFP36, BATF, PLAG1, KLF4, BCL11B, ZFP69B, ZKSCAN8, ZBTB6, MED, BCL6B, EGR2, ELF3, ARID4B, EGLN2, ZNF366, MAML3, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, SMARCA2, ZNF660, HNF1A, KDM4B, ZNF101, PBX2, ZNF596, TSC22D4, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, MAF, JMJD1C, MYOG, ELF1, RBM39, SNAI2, KLF10, ZNF624, CTCF, JUN, LMO1, ZBTB20, MNT, DPF2, RYBP, IRF4, ZNF423, DDX20, PDX1, RBPJ, TFAP2C, MLX, ZNF239, MTA2, ZNF317, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, PHB2, PBX1, TSHZ1, ZNF2, FOXP2, HOMEZ, RXRA, NKX3-1, PRDM14, LEF1, MIER3, HNRNPH1, VDR, NR3C1, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, ZBTB24, EZH2phosphoT487, LDB1, AFF4, SOX13, ZFP3, ZNF770, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, DAXX, NFIB, ZNF48, PRDM9, ZEB2, HMBOX1, PBX3, ETV6, ZNF10, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, ZBTB18, KLF9, ZNF41, TBX5, USF1, BCL11A, SP1, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, ZNF623, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, ZKSCAN1, KLF7, KDM1A, BRG1, ISL1, ZIC2, GATA3, KLF15, TAL1, ZNF143, MTA1, AGO2, CBX2, TP53, ZNF645, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, RNF2, IKZF2, BRD4, JUND, ZSCAN23, TBX2, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, TFAP4, CHD7, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, SAP30, ESR1, TP73, ZNF524, KLF1, ZNF695, SOX4, E2F6, TRIM24, ZNF92, GTF2F1, GLIS1, ZSCAN5D, ZNF778, ZBTB1, ZSCAN5A, ZMYND8, ERG2, SP4, TBP, HOXC5, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, EZH2, ZNF652, ZNF436, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, MYBL2, RARA, ZNF35, ZNF384, CREBBP, NFYC, HMGB2, ZNF518A, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, GTF3C2, SREBF2, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, HOXA9, HNRNPLL, BCOR, FOXP1, ZNF684, AATF, ZNF34, CXXC4, PPARG, ZNF692, GTF2B, JDP2, ZNF574, TCF7, ZNF823, FOXO3, ZNF318, RELA, TARDBP, CHAMP1, ZNF282, MAX, GFI1B, TCF7L2, NEUROG2, KDM5B, NR2F1, ZNF791, PKNOX1, MYOD1, AR, PAX3-FOXO1, ZBTB16, ZNF324, RBAK, HEXIM1, ZNF280D, ZNF395, AHR, FOSL2, DMAP1, ZNF391, HMG20A, ZSCAN5C, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, LYL1, ZNF274, INSM2, NFIC, ZNF362, PRDM1, KLF14, MECOM, HDAC3, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, EP300, BAF155, ZNF302, PRDM4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, ID3, RUNX1T1, MLLT3, GATAD1, ARID3A, ASCL1, MIER1, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, ZNF750, FEZF1, HES1, ZNF664, TFE3, EHF, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, MAFG, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, CBX8, TWIST1, ZNF701, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, SMAD2, CDK6, NRF1, PBX4, NR2C1, FOS, CHD1, MED1, ZNF558, MYB, CEBPD, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, GLI2, CCNT2, POU2F3, PHIP, TCF3, SKI, PAX7, ZNF283, KLF13, FOXA2, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ASXL1, ZNF610, SP140, HIF1A, BHLHE22, OTX2, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NR2F2, ZNF83, ZNF213, ZNF843, BHLHE40, NFKBIZ, TAF1, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, MEF2D, ZNF24
- Target gene symbol (double-evidenced CRMs): ETS2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 19
- Related genes and loops