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Basic information

CohesinDB ID: CDBP00419358

Locus: chr21-38999239-39001723

Data sourse: ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE103477, GSE111537, GSE131606, ENCSR917QNE, ENCSR000EFJ, GSE67783, GSE86191, GSE101921, GSE206145-NatGen2015, GSE120943, GSE94872, GSE118494, GSE98367, ENCSR000EHW, GSE206145, ENCSR000EHX, ENCSR167MTG, ENCSR000HPG, GSE111913, ENCSR054FKH, GSE68388

Cell type: MCF-7, Macrophage, RPE, Fibroblast, HCT-116, Monocytes, Hep-G2, THP-1, HUVEC, HCAEC, IMR-90, SK-N-SH, RT-112, Liver, OCI-AML-3, HSPC, HuCC-T1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 10% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.800

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 34%, "15_Quies": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, HMG20A, XBP1, FOXA1, RXRB, MLL4, TFAP4, LYL1, ATF3, NFIC, ZFP64, PAX5, MAF, JMJD1C, TEAD1, KLF6, SNAI2, ESR1, OCA2, PITX3, CTCF, TCF12, JUN, EP300, SOX5, TRIM24, E2F1, SMC1, TEAD4, KMT2B, FOXA3, GLIS1, POU2F2, ZSCAN5D, MYCN, ZNF263, TOP2A, ZBTB48, STAT1, SAP130, ERG2, HOXC5, ETS1, MYC, HOMEZ, RAD21, ARID1B, GRHL3, STAT3, XRCC5, IKZF1, RCOR1, VDR, NR3C1, CEBPB, STAT5B, KMT2A, EZH2, EBF3, GABPB1, ZHX2, SPI1, TFE3, EHF, IRF1, GATA2, INTS13, MXD3, FLI1, NFIL3, ZNF554, ETV5, RUNX1, BCL6, CEBPA, NKX2-2, SOX13, ZFX, SMAD3, CBX8, ERG3, RARA, CREBBP, NOTCH1, ZNF184, PBX4, DAXX, HMGB2, ZNF48, SMAD4, PBX3, FOS, CDK8, SMARCB1, MED1, TEAD3, ZEB1, MYB, IKZF5, ARID1A, ZBTB7A, FOXP1, SMC3, STAG1, MLLT1, STAG2, FOXA2, EBF1, CHD2, WT1, ESR2, MEF2C, CDK9, KDM1A, YY1, RELA, JUNB, ISL1, GATA3, TAL1, MAX, ZNF143, GATA1, HAND2, KLF4, NCOA3, NR2F2, KDM5B, TP53, MED, MYOD1, PHOX2B, ELF3, BRD2, KAT8, ARID4B, AR, RXR, EGR1, ZBTB26, RNF2, HSF1, BRD4, JUND, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): ERG,GET1,GET1-SH3BGR,LCA5L,SH3BGR,ETS2,PSMG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000185437,

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Deatailed information for cohesin site CDBP00419358