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Basic information

CohesinDB ID: CDBP00419359

Locus: chr21-39002157-39005860

Data sourse: ENCSR230ZWH, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE131606, GSE165895, ENCSR000EFJ, ENCSR917QNE, GSE67783, GSE86191, GSE101921, GSE206145-NatGen2015, GSE120943, GSE94872, GSE98367, ENCSR879KXD, GSE206145, GSE55407, ENCSR000HPG, GSE83726, GSE73207

Cell type: MDM, RH4, Liver, H9-hESC, RPE, Fibroblast, IMR-90, K-562, DKO, HFFc6, Monocytes, TF-1, SK-N-SH, THP-1, Macrophage, HCT-116, HUVEC, HCAEC, OCI-AML-3, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 10% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.778

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 37%, "5_TxWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, CHD8, POU5F1, ZNF263, MYCN, ID3, ZFX, DUX4, WT1, ZBTB48, ZNF770, TET2, YY1, ATF3, MYC, SP140, ZIC2, ARNT, OTX2, ATF2, PRDM9, PDX1, SCRT2, CREB1, EZH2, MLLT1, ESR1, EP300, AR, PAX3-FOXO1, HSF1, BRD4, SCRT1, MAZ, STAG1

Target gene symbol (double-evidenced CRMs): GET1,ERG,SH3BGR,PSMG1,ETS2,LCA5L,GET1-SH3BGR

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 20

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000185437,

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Deatailed information for cohesin site CDBP00419359