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Basic information

CohesinDB ID: CDBP00419360

Locus: chr21-39006216-39008144

Data sourse: ENCSR000BTU, ENCSR230ZWH, GSE111537, GSE67783, GSE138405, GSE72082, GSE86191, GSE98367, GSE111913, GSE206145, GSE101921, GSE55407, GSE206145-NatGen2015, GSE120943, GSE103477, ENCSR703TNG, GSE126990, GSE108869, GSE94872, ENCSR917QNE

Cell type: MCF-7, RPE, HMEC, Hela-Kyoto, Fibroblast, HCT-116, Monocytes, THP-1, Ishikawa, HUVEC, HCAEC, HeLa-S3, RT-112, Liver, OCI-AML-3, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.811

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 33%, "15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, HMG20A, LCORL, ZNF621, MEIS2, XBP1, FOXA1, HLF, SUZ12, PBX2, LEO1, MTA2, ZFHX2, TFAP4, ZBTB7B, HDGF, TSC22D4, LYL1, ZNF274, ATF3, BMI1, INSM2, CTCFL, CHD7, PRDM1, ZNF444, CBFB, MECOM, SMARCE1, TP63, ZSCAN4, MITF, JMJD1C, MAF, KLF5, ELF1, TRIM28, TEAD1, ETV1, SNAI2, NFE2L2, BCLAF1, LMO2, ESR1, OCA2, RCOR2, MLL, HDAC8, JUN, TCF12, CTCF, EP300, E4F1, KLF1, LMO1, ARID5B, POU2F1, SOX5, DPF2, ZNF157, MNT, PAX8, TRIM24, RFX5, SOX6, ZNF211, ZNF512B, E2F1, SMC1, TEAD4, ZNF92, KMT2B, FOXA3, GATAD2A, EHMT2, TFAP2C, RBPJ, POU2F2, GLIS1, YBX1, NANOG, CHD8, BRD1, ZSCAN5D, SRC, MYCN, RUNX1T1, ID3, CDK7, CTBP1, ERF, TOP2A, ZBTB48, DUX4, STAT1, ZSCAN5A, ZNF205, MLLT3, ZSCAN21, SAP130, DDX5, ERG2, NBN, NONO, ARID3A, ERG, ZBTB21, PBX1, ASCL1, ZNF341, ETS1, MYC, MCM5, SMARCA4, RFX1, ARID1B, RAD21, FOXP2, POU5F1, GRHL3, RXRA, FOXK2, GABPA, STAT3, ZNF614, UBN1, SOX10, XRCC5, IKZF1, RCOR1, LEF1, NR2F6, NFE2, VDR, GFI1, NR3C1, ESRRA, CEBPB, ZNF750, STAT5B, SRSF3, KMT2A, CREB1, EZH2, EBF3, SPI1, HES1, MIXL1, EHF, TFE3, KLF17, IRF1, HDAC2, GATA2, SSRP1, GATAD2B, SREBF1, FLI1, HCFC1, NR2C2, DRAP1, SMARCA5, ZNF785, ZNF490, HEXIM1-CDK9, NFIL3, NCOA2, MRTFB, ATF1, PTBP1, ETV5, RUNX1, SMC1A, CBX1, HDAC1, CEBPA, SIRT6, BCL6, SIN3A, ZFX, ZNF335, SOX13, SMAD3, TET2, ERG3, MCM2, TRIM22, TWIST1, DNMT3B, ZNF18, RARA, ZBTB2, NOTCH1, TAF15, ZNF169, RUNX2, ZNF184, ARNT, DAXX, PBX4, NFIB, ZBTB10, ZNF48, ATF2, ZEB2, SMAD4, CBFA2T3, PBX3, NR2C1, FOS, CDK8, MED1, TEAD3, TERF1, MYB, ZMYM3, SMAD1, VEZF1, HNRNPH1, NR1H2, NCOA1, L3MBTL2, EVI1, SREBF2, STAT5A, KLF16, SETDB1, BCL11A, SP1, TFAP2A, NR4A1, NIPBL, FOXA2, PHF20, ARID2, REST, ZBTB7A, RBM25, ATF7, POU2F3, ZNF263, ASH2L, TCF3, BCOR, FOXP1, AATF, SMC3, NCOR2, MLLT1, STAG1, STAG2, ETV4, SKI, ZNF239, PPARG, CBX3, MTA3, CREM, MEIS1, SS18, EBF1, TBL1X, NFATC1, ZNF207, WT1, ESR2, FOXF1, ZNF662, MEF2C, ZBTB33, CDK9, ZNF8, ZNF580, BCL3, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, JUNB, ZNF148, NEUROD1, MCM3, SP140, TCF4, SKIL, HIF1A, ZFP36, BHLHE22, GATA3, OTX2, ZNF311, ZNF639, TAL1, MAX, GATA1, ZNF143, CEBPG, BCL11B, KLF4, GFI1B, NR2F2, ZNF592, NCOA3, NR2F1, NEUROG2, KDM5B, ZNF768, TP53, PKNOX1, ZNF791, ZNF687, MED, ZNF334, NFKB1, MYOD1, EGR2, ELF3, ZFP28, TBX21, BHLHE40, AR, RXR, YAP1, EGR1, ZBTB1, HSF1, RNF2, NCOR1, JUND, BRD4, ZBTB26, MAZ, ZSCAN23, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): SH3BGR,PSMG1,LCA5L,ETS2,GET1-SH3BGR,GET1,ERG

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 18

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000185437,

eachgene

Deatailed information for cohesin site CDBP00419360