- Basic information
- CohesinDB ID: CDBP00419362
- Locus: chr21-39010386-39017610
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE25021, GSE108869, GSE115602, ENCSR000EFJ, GSE165895, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, GSE130135, ENCSR703TNG, GSE118494, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE85526, GSE206145, ENCSR000EHX, ENCSR767DFK, GSE97394, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE73207
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Cell type: MDM, GM2610, OCI-AML-3, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, HeLa-S3, IMR-90, K-562, HFFc6, H1-hESC, Monocytes, TF-1, GM12891, SK-N-SH, GM19239, RT-112, THP-1, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HCAEC, HeLa, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 27% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.644
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 27%,
"7_Enh": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PAX3-FOXO1, RUNX2, ZFX, DUX4, ZNF143
- Target gene symbol (double-evidenced CRMs): GET1-SH3BGR,ERG,SH3BGR,ETS2,GET1,LCA5L,PSMG1
- Function elements
- Human SNPs: Nicotine_dependence_symptom_count
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 34
- Related genes and loops
- Related gene:
ENSG00000157554,
ENSG00000157557,
ENSG00000183527,
ENSG00000285815,
ENSG00000182093,
ENSG00000157578,
ENSG00000185437,
- Related loop:
chr21:38450000-38475000~~chr21:39000000-39025000,
chr21:38575000-38600000~~chr21:39000000-39025000,
chr21:38650000-38675000~~chr21:39000000-39025000,
chr21:38733115-38735253~~chr21:39022229-39023588,
chr21:38733127-38735189~~chr21:39020330-39024316,
chr21:38733295-38735171~~chr21:39022214-39024026,
chr21:38800000-38825000~~chr21:39000000-39025000,
chr21:38804148-38807306~~chr21:39011954-39013137,
chr21:38804148-38807306~~chr21:39022163-39023870,
chr21:38804397-38807388~~chr21:39020330-39024316,
chr21:38830488-38833913~~chr21:39020753-39024286,
chr21:38897047-38898311~~chr21:39016372-39018255,
chr21:38900000-38925000~~chr21:39000000-39025000,
chr21:39000000-39025000~~chr21:39150000-39175000,
chr21:39000000-39025000~~chr21:39375000-39400000,
chr21:39000000-39025000~~chr21:39425000-39450000,
chr21:39006962-39008700~~chr21:39066299-39068801,
chr21:39020753-39024286~~chr21:39046917-39049378,