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Basic information

CohesinDB ID: CDBP00419364

Locus: chr21-39019594-39020196

Data sourse: GSE138405, GSE67783, GSE98367

Cell type: Hela-Kyoto, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,SA2,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 42%, "5_TxWk": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, TRIM25, HMG20A, SOX2, HNF1A, XBP1, FOXA1, HLF, SUZ12, RBFOX2, RXRB, PBX2, MLL4, ZFHX2, KDM3A, TFAP4, TSC22D4, LYL1, THRB, ATF3, NFIC, ZFP64, RUNX3, CHD7, ZNF444, CBFB, MXD4, MECOM, PAX5, TP63, JMJD1C, MYOG, KLF5, TEAD1, TRIM28, BCLAF1, KLF6, RBM39, ELF1, KLF10, LMO2, ESR1, RCOR2, NFE2L2, SNAI2, USF2, JUN, TCF12, CTCF, EP300, KLF1, E4F1, MNT, SOX9, SOX5, DPF2, PAX8, SOX4, DMAP1, RYBP, TRIM24, IRF4, E2F6, DEK, E2F4, E2F1, ZNF528, SMC1, RFX3, TEAD4, KMT2B, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, EED, MLX, TFAP2C, POU2F2, CHD8, BRD1, MYCN, POU5F1, RUNX1T1, KDM4C, BRD3, CTBP1, MTA2, ZBTB48, STAT1, SRF, GATAD1, SAP130, ERG2, TBP, HNF4G, ERG, PBX1, ASCL1, OGG1, ETS1, MYC, SMARCA4, KDM4A, HOMEZ, RAD21, FOXP2, GRHL3, RXRA, GABPA, APC, ZNF614, XRCC5, STAT3, IKZF1, NFE2, MIER3, NR2F6, RCOR1, VDR, NR3C1, CEBPB, SRSF3, ZNF750, HNRNPL, ESRRA, KMT2A, CREB1, TBL1XR1, EZH2, GRHL2, ZNF652, EBF3, GABPB1, ZHX2, SPI1, TFE3, MIXL1, HBP1, PCBP1, HDAC2, GATA2, ZNF182, ZNF644, GATAD2B, MXD3, SIX2, FLI1, DRAP1, ZGPAT, HCFC1, SMARCA5, NFIL3, ZIM3, MYF5, ETV5, PTBP1, RUNX1, THAP11, SMC1A, BCL6, CEBPA, MTA3, CBX1, SOX13, ZFX, SIN3A, FIP1L1, AFF4, SMAD3, PCBP2, ZNF770, TET2, TBX3, SP5, ERG3, TRIM22, TWIST1, SMARCC1, MYBL2, RARA, NFYC, NOTCH1, ZBTB2, TAF15, RUNX2, CDK6, GATA4, RBBP5, PBX4, ARNT, NRF1, ZNF48, PRDM9, SMAD4, ZEB2, ETV6, MAFB, FOXM1, FOS, CDK8, HMGXB4, SMARCB1, CHD1, MED1, TEAD3, CEBPD, MYB, KDM6B, ZMYM3, U2AF1, NR1H2, L3MBTL2, EVI1, HIF2A, STAT5A, TBX5, SREBF2, USF1, BCL11A, SP1, NIPBL, NR4A1, HNF4A, IKZF5, REST, ZBTB7A, ARID1A, RBM25, ZNF479, ZHX1, ASH2L, HNRNPLL, TCF3, FOXP1, AATF, SMC3, ELL2, MLLT1, STAG1, ETV4, NFATC3, SKI, STAG2, TRP47, CBFA2T2, PPARG, AGO1, FOXA2, EBF1, CREM, SS18, CHD2, ZNF600, MIER2, GTF2B, WT1, MAFF, ESR2, MEF2C, TCF7, CDK9, ZNF580, HOXB13, FOXO3, KDM1A, YY1, RELA, ZKSCAN1, JUNB, SP140, TCF4, HIF1A, ZFP36, BHLHE22, GATA3, BATF, TAL1, MAX, MAF1, SPIB, GATA1, AGO2, ZNF143, PLAG1, CBX2, CEBPG, BCL11B, KLF4, GFI1B, NR2F2, NR2F1, TCF7L2, KDM5B, NEUROG2, TP53, MED, ZNF334, NFKB1, MYOD1, EGR2, ELF3, PHF5A, KAT8, T, TBX21, NFKBIZ, AR, BHLHE40, ARID4B, ZBTB16, TAF1, YAP1, EGLN2, EGR1, ZBTB26, RNF2, IKZF2, BRD4, HSF1, JUND, ILF3, CUX1, MAZ, SMAD4.1D12, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): GET1,PSMG1,ERG,LCA5L,SH3BGR,GET1-SH3BGR,ETS2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000185437,

eachgene

Deatailed information for cohesin site CDBP00419364