- Basic information
- CohesinDB ID: CDBP00419371
- Locus: chr21-39035632-39038463
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE106870, GSE145327, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, GSE38411, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE131577
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Cell type: MDM, RH4, CVB-hiPSC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, K-562, BCBL-1, H1-hESC, Monocytes, GM18505, SK-N-SH, RT-112, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, HL-60, Hep-G2, HCAEC, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 17% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.689
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 44%,
"5_TxWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, PGR, HMG20A, ZNF660, HNF1A, XBP1, FOXA1, SUZ12, RBFOX2, RXRB, PBX2, MLL4, KDM3A, TFAP4, TSC22D4, ZNF90, THRB, ATF3, NFIC, ZFP64, THAP1, CTCFL, PRDM1, CBFB, MXD4, TP63, MITF, MAF, JMJD1C, TEAD1, ELF1, KLF6, RBM39, ETV1, KLF10, RCOR2, ESR1, OCA2, USF2, CTCF, TCF12, JUN, EP300, MNT, SOX9, SOX5, DPF2, DMAP1, E2F6, RFX5, RFX3, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, RBPJ, TFAP2C, MLX, GLIS1, POU2F2, ZSCAN5D, MYCN, HHEX, CDK7, POU5F1, RUNX1T1, CTBP1, KDM4C, DUX4, ZBTB48, STAT1, ZSCAN5A, SRF, GATAD1, SAP130, GMEB2, ARID3A, TBP, HNF4G, ERG, PBX1, OGG1, ETS1, MYC, EZH1, SMARCA4, ONECUT1, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, MCRS1, GABPA, STAT3, ZNF614, XRCC5, PRDM14, IKZF1, MIER3, RCOR1, NR2F6, HNRNPH1, CEBPB, SRSF3, HNRNPL, KMT2A, CREB1, CCAR2, TBL1XR1, EZH2, GRHL2, ZNF652, GABPB1, ZHX2, HES1, TFE3, MIXL1, HBP1, ZSCAN2, EHF, HDAC2, SSRP1, ZNF644, GATAD2B, MXD3, FLI1, DRAP1, ZGPAT, MXI1, HCFC1, SMARCA5, NFIL3, ATF1, ETV5, PTBP1, RUNX1, THAP11, CTNNB1, BCL6, CBX1, CEBPA, SMC1A, SIRT6, SOX13, ZFX, SIN3A, FIP1L1, SMAD3, TET2, CBX8, TBX3, SP5, ERG3, SMARCC1, MYBL2, RARA, PRPF4, NOTCH1, IRF2, ZNF384, NFYC, ZBTB2, GATA4, ARNT, ZNF48, SMAD4, FOS, HMGXB4, SMARCB1, TGIF2, MED1, TEAD3, ZEB1, CEBPD, U2AF1, ZMYM3, ZNF3, NR1H2, KLF9, L3MBTL2, TBX5, MBD1, SETDB1, RBM22, USF1, SP1, TFAP2A, NIPBL, HNF4A, NR4A1, BCL11A, IKZF5, REST, ZBTB7A, RBM25, ASH2L, HNRNPLL, ZNF605, TCF3, FOXP1, BCOR, AATF, SMC3, STAG1, ETV4, SKI, TRP47, CBFA2T2, PPARG, FOXA2, AGO1, EBF1, CREM, MEIS1, TBL1X, MIER2, CBX3, MTA3, WT1, MAFF, ZBTB33, TCF7, ZNF580, ZKSCAN1, FOXO3, KDM1A, YY1, RELA, JUNB, SP140, ZFP36, HIF1A, MGA, TAL1, MAX, GATA1, ZNF143, CBX2, CEBPG, NCOA3, NR2F2, NR2F1, ZNF768, TP53, RUVBL1, PHOX2B, PHF5A, ELF3, KAT8, BRD2, ARID4B, NFKBIZ, BHLHE40, TAF1, AR, RXR, EGLN2, EGR1, HEXIM1, RB1, HSF1, ZBTB26, RNF2, BRD4, JUND, NCOR1, CLOCK, CUX1, MAZ, SMAD4.1D12, TBX2, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): ETS2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 11
- Related genes and loops