- Basic information
- CohesinDB ID: CDBP00419377
- Locus: chr21-39046431-39047128
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Data sourse: GSE67783, GSE86191, GSE98367, GSE206145, GSE101921, GSE206145-NatGen2015, GSE120943, GSE94872
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Cell type: RPE, Fibroblast, HCT-116, Monocytes, HUVEC, HCAEC, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 62%,
"7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: POU2F2, CHD8, ZSCAN5D, MYCN, TOP2A, RUNX1T1, ZFX, NME2, DUX4, ZBTB48, WT1, ZSCAN5A, STAT1, FOXA1, HOXB13, YY1, RELA, CREBBP, ZNF384, ASCL1, JUNB, ETS1, MYC, RAD21, SP140, GRHL3, HIF1A, GABPA, STAT3, TAL1, TP63, ZNF143, FOS, GATA1, ZNF736, TEAD3, ZNF573, ESR1, OCA2, ZNF334, CTCF, JUN, SPI1, BAF155, AR, GATA2, HEXIM1, HSF1, NOTCH3, SCRT1, SMC1, SMC3, STAG1, TFAP2C
- Target gene symbol (double-evidenced CRMs): ETS2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 5
- Related genes and loops
- Related gene:
ENSG00000157557,
- Related loop:
chr21:38525000-38550000~~chr21:39050000-39075000,
chr21:38700000-38725000~~chr21:39050000-39075000,
chr21:38800000-38825000~~chr21:39025000-39050000,
chr21:38800000-38825000~~chr21:39050000-39075000,
chr21:38818748-38820756~~chr21:39047115-39049516,
chr21:38850000-38875000~~chr21:39050000-39075000,
chr21:38875000-38900000~~chr21:39025000-39050000,
chr21:38875000-38900000~~chr21:39050000-39075000,
chr21:38900000-38925000~~chr21:39025000-39050000,
chr21:38900000-38925000~~chr21:39050000-39075000,
chr21:38925000-38950000~~chr21:39025000-39050000,
chr21:38925000-38950000~~chr21:39050000-39075000,
chr21:38950000-38975000~~chr21:39050000-39075000,
chr21:39020753-39024286~~chr21:39046917-39049378,