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Basic information

CohesinDB ID: CDBP00419378

Locus: chr21-39047690-39048980

Data sourse: ENCSR000BLD, ENCSR000EEG, GSE72082, GSE138405, GSE111913, ENCSR404BPV, GSE101921, ENCSR000ECE, ENCSR054FKH, GSE85526, ENCSR198ZYJ, GSE68388, GSE206145-NatGen2015, ENCSR703TNG, GSE126990, GSE108869, GSE165895

Cell type: MCF-7, H1-hESC, HMEC, Fibroblast, Hela-Kyoto, MCF-10A, HEKn, Hep-G2, Neurons-H1, HeLa-S3, RT-112, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 57%, "7_Enh": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SMARCA2, HMG20A, SOX2, PBX2, ZFP64, CHD7, ZNF383, TP63, ZNF467, ELF1, TRIM28, KLF6, SAP30, ESR1, JUN, CTCF, TCF12, EP300, GATA6, SOX5, ZNF528, RFX3, SMC1, TEAD4, TFAP2C, GLIS1, POU2F2, POU5F1, MYCN, DUX4, ZBTB48, STAT1, SAP130, TBP, ZNF585B, ETS1, MYC, SMARCA4, RFX1, RAD21, STAT3, IKZF1, RCOR1, ZNF750, CEBPB, NR3C1, CCAR2, EBF3, SPI1, EHF, MXD3, ZNF146, FLI1, HEXIM1-CDK9, SMC1A, AFF4, SIN3A, SMAD3, SMARCC1, RUNX2, GATA4, OSR2, PBX4, PBX3, MAFB, ZNF10, FOS, CDK8, MED1, TEAD3, USF1, BCL11A, SP1, NIPBL, REST, PHIP, SMC3, NCOR2, STAG2, FOXA2, KDM1A, RELA, JUNB, HIF1A, GATA3, MAX, GATA1, HAND2, KLF4, SP7, KDM5B, TP53, PKNOX1, ZBTB6, NFKB1, PHOX2B, BRD2, ELF3, NFKBIZ, AR, PAX3-FOXO1, BRD4, MAZ, TBX2, FOSL2

Target gene symbol (double-evidenced CRMs): ETS2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000157557,

eachgene

Deatailed information for cohesin site CDBP00419378