- Basic information
- CohesinDB ID: CDBP00419380
- Locus: chr21-39050368-39052319
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Data sourse: ENCSR000EFJ, ENCSR000HPG, GSE101921, GSE135093, GSE85526, GSE206145-NatGen2015, GSE68388, GSE165895
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Cell type: HMEC, Fibroblast, HEKn, IMR-90, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 43%,
"5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: SMC1A, BRD1, CHD8, FOXA2, ZFX, ZSCAN16, SMAD3, FOXA1, ZNF770, CDK9, SMARCC1, KDM1A, RELA, JUNB, ATF3, RUNX2, NFIC, SMARCA4, GATA4, CTCFL, RAD21, MYC, PBX4, NRF1, OTX2, GATA3, MORC2, STAT3, MAX, TP63, PBX3, FOS, CDK8, RCOR1, ZNF143, MED1, ZNF750, CEBPB, NR3C1, MYOG, NCOA3, TEAD3, SCRT2, SNAI2, TP53, TP73, JUN, TCF12, MAFK, EP300, SPI1, BCL11A, EHF, CTCF, ZHX2, BHLHE40, PAX8, AR, ZBTB26, BRD4, SCRT1, MAZ, SMC1, SMC3, ZNF175, STAG2, FOSL2
- Target gene symbol (double-evidenced CRMs): ERG,ETS2
- Function elements
- Human SNPs: Colorectal_cancer
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 9
- Related genes and loops
- Related gene:
ENSG00000157554,
ENSG00000157557,
- Related loop:
chr21:38525000-38550000~~chr21:39050000-39075000,
chr21:38700000-38725000~~chr21:39050000-39075000,
chr21:38800000-38825000~~chr21:39025000-39050000,
chr21:38800000-38825000~~chr21:39050000-39075000,
chr21:38818748-38820756~~chr21:39047115-39049516,
chr21:38850000-38875000~~chr21:39050000-39075000,
chr21:38875000-38900000~~chr21:39025000-39050000,
chr21:38875000-38900000~~chr21:39050000-39075000,
chr21:38900000-38925000~~chr21:39025000-39050000,
chr21:38900000-38925000~~chr21:39050000-39075000,
chr21:38925000-38950000~~chr21:39025000-39050000,
chr21:38925000-38950000~~chr21:39050000-39075000,
chr21:38950000-38975000~~chr21:39050000-39075000,
chr21:39020753-39024286~~chr21:39046917-39049378,