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Basic information

CohesinDB ID: CDBP00419385

Locus: chr21-39060621-39063414

Data sourse: ENCSR000BLD, GSE72082, GSE116868, GSE105028, GSE25021, GSE131606, ENCSR000EDW, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, ENCSR000EEG, GSE98367, ENCSR000BLS, GSE206145, ENCSR000BTQ, ENCSR167MTG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388

Cell type: MCF-7, H1-hESC, Macrophage, Fibroblast, HCT-116, Monocytes, Hep-G2, MB157, RPE, DKO, RT-112, K-562, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 10% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 54%, "14_ReprPCWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, XBP1, SUZ12, PBX2, ATF3, RUNX3, ZSCAN4, ZNF506, TEAD1, TRIM28, SNAI2, LMO2, ESR1, OCA2, CTCF, MNT, E2F4, E2F1, TFAP2C, BRD1, ZSCAN5D, MYCN, POU5F1, RUNX1T1, TOP2A, ZNF263, ZBTB48, DUX4, DDX5, ERG2, ERG, ASCL1, OGG1, MYC, SMARCA4, RAD21, GRHL3, XRCC5, NR3C1, EZH2, GRHL2, GABPB1, SPI1, SIX2, RUNX1, CTNNB1, SMC1A, CBX1, SIRT6, ZFX, TET2, ERG3, ZBTB2, RUNX2, PBX4, DAXX, ATF2, PRDM9, FOS, TEAD3, SCRT2, BCL11A, GSPT2, IKZF5, AATF, SMC3, STAG1, ZNF283, TRP47, MEF2B, TBL1X, AGO1, WT1, KDM1A, ZNF19, YY1, RELA, NEUROD1, JUNB, MCM3, SP140, BATF, MAF1, MAX, SPIB, ZNF143, PLAG1, NEUROG2, NR2F1, KDM5B, TP53, EGR2, AR, RXR, EGR1, HSF1, ZBTB26, SCRT1, BRD4, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): ERG,ETS2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 21

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557,

eachgene

Deatailed information for cohesin site CDBP00419385