- Basic information
- CohesinDB ID: CDBP00419387
- Locus: chr21-39066759-39067914
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Data sourse: ENCSR000BLD, ENCSR000BTQ, ENCSR167MTG, ENCSR230ZWH, GSE67783, GSE72082, GSE86191, ENCSR000BLY, ENCSR000BLS, GSE105028, GSE101921, GSE206145-NatGen2015, GSE83726, ENCSR703TNG, GSE25021, GSE116344, GSE94872, ENCSR917QNE
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Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, RH4, Hep-G2, HUVEC, HCAEC, SK-N-SH, Liver, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 60%,
"7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PGR, XBP1, FOXA1, ATF3, PRDM1, PAX5, TEAD1, TRIM28, LMO2, ESR1, OCA2, JUN, CTCF, BAF155, GATA6, SOX5, PAX8, TRIM24, SOX6, ZNF528, SMC1, ZNF280A, ZNF92, EED, GLIS1, POU2F2, CHD8, ZSCAN5D, POU5F1, MYCN, CTBP1, ZBTB48, MLLT3, ERG, ETS1, MYC, RAD21, GRHL3, NKX3-1, IKZF1, RCOR1, HNRNPH1, NR2F6, NR3C1, CREB1, EZH2, BMPR1A, GRHL2, TRPS1, HDAC2, GATA2, ZNF554, RUNX1, BCL6, SMC1A, SOX13, ZFX, SIN3A, POU4F2, CREBBP, ZNF35, NOTCH1, RUNX2, CDK6, GATA4, ARNT, HMGB2, FOS, CDK8, MYB, PIAS1, ZNF331, SMAD1, C11orf30, SETDB1, EVI1, USF1, BCL11A, ZNF479, POU2F3, ZNF605, CTBP2, FOXP1, SMC3, STAG1, STAG2, TRP47, PPARG, FOXA2, ZSCAN16, WT1, HOXB13, KDM1A, YY1, RELA, JUNB, NEUROD1, SP140, HIF1A, OTX2, GATA3, TAL1, MAX, ZNF449, ZNF143, GATA1, CBX2, TLE3, ZFP69B, NCOA3, NR2F2, GFI1B, NR2F1, TCF7L2, KDM5B, T, AR, EGLN2, HSF1, RNF2, NOTCH3, BRD4, JUND, SCRT1, ZNF316
- Target gene symbol (double-evidenced CRMs): ETS2,ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000157554,
ENSG00000157557,
- Related loop:
chr21:38525000-38550000~~chr21:39050000-39075000,
chr21:38700000-38725000~~chr21:39050000-39075000,
chr21:38732695-38735241~~chr21:39066299-39068801,
chr21:38732707-38735284~~chr21:39066439-39068713,
chr21:38732918-38735320~~chr21:39066991-39068385,
chr21:38733115-38735333~~chr21:39066051-39068459,
chr21:38733311-38735294~~chr21:39065920-39068738,
chr21:38800000-38825000~~chr21:39050000-39075000,
chr21:38804213-38806093~~chr21:39065920-39068738,
chr21:38850000-38875000~~chr21:39050000-39075000,
chr21:38875000-38900000~~chr21:39050000-39075000,
chr21:38900000-38925000~~chr21:39050000-39075000,
chr21:38925000-38950000~~chr21:39050000-39075000,
chr21:38950000-38975000~~chr21:39050000-39075000,
chr21:38992131-38994558~~chr21:39065920-39068738,
chr21:39006962-39008700~~chr21:39066299-39068801,
chr21:39061365-39062529~~chr21:39125341-39127059,