- Basic information
- CohesinDB ID: CDBP00419390
- Locus: chr21-39079018-39081868
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Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE111537, GSE25021, ENCSR000EDW, ENCSR917QNE, GSE67783, GSE86191, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000EHX, GSE55407, ENCSR167MTG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126755
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Cell type: MCF-7, H1-hESC, Macrophage, Fibroblast, HCT-116, Monocytes, Hep-G2, RH4, RPE, THP-1, OCI-AML-3, RT-112, SK-N-SH, K-562, Liver, Neutrophil, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.800
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 42%,
"14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, PGR, HMG20A, XBP1, FOXA1, HLF, RXRB, ZFHX2, KDM3A, TFAP4, TSC22D4, LYL1, ATF3, CHD7, PRDM1, MECOM, PAX5, JMJD1C, TEAD1, TRIM28, ELF1, LMO2, ESR1, MLL, RCOR2, CTCF, TCF12, EP300, SOX5, E2F6, DMAP1, TRIM24, IRF4, E2F4, KMT2B, FOXA3, ZNF175, GATAD2A, TFAP2C, RBPJ, CHD8, ZSCAN5D, POU5F1, MYCN, TOP2A, ZBTB48, STAT1, GATAD1, SAP130, ERG2, HNF4G, ERG, ETS1, MYC, ONECUT1, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, GABPA, STAT3, XRCC5, ZNF614, RCOR1, NFE2, NR2F6, MIER3, VDR, ZNF750, CEBPB, NR3C1, KMT2A, CREB1, EZH2, ZNF652, GABPB1, ZHX2, SPI1, TFE3, MIXL1, IRF1, HDAC2, GATA2, INTS13, ZNF644, FLI1, DRAP1, ZGPAT, NFIL3, ATF1, PTBP1, ETV5, RUNX1, THAP11, SMC1A, BCL6, CEBPA, CBX1, SOX13, ZFX, PCBP2, TET2, CBX8, ERG3, SP5, RARA, PRPF4, CDK6, ARNT, SMAD4, FOS, CDK8, MED1, TEAD3, CEBPD, MYB, PIAS1, ZMYM3, MBD1, STAT5A, SP1, BCL11A, HNF4A, IKZF5, REST, RBM25, ASH2L, BCOR, TCF3, FOXP1, SMC3, MLLT1, STAG1, SKI, CBFA2T2, PPARG, FOXA2, CREM, MIER2, ZSCAN16, WT1, MEF2C, ZBTB33, CDK9, HOXB13, ZNF580, KDM1A, YY1, RELA, SP140, ZFP36, TCF4, HIF1A, BHLHE22, TAL1, MAX, ZNF143, CEBPG, NR2F2, NR2F1, KDM5B, ZBTB6, EGR2, ELF3, PHF5A, KAT8, NFKBIZ, AR, ARID4B, RXR, EGR1, HSF1, NCOR1, ZBTB26, BRD4, SCRT1, JUND, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): ETS2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 17
- Related genes and loops
- Related gene:
ENSG00000157557,
- Related loop:
chr21:17425000-17450000~~chr21:39075000-39100000,
chr21:38525000-38550000~~chr21:39050000-39075000,
chr21:38700000-38725000~~chr21:39050000-39075000,
chr21:38732732-38735278~~chr21:39086152-39087364,
chr21:38732774-38735251~~chr21:39086169-39087327,
chr21:38732918-38735320~~chr21:39083341-39084889,
chr21:38732918-38735320~~chr21:39086131-39087401,
chr21:38733392-38735200~~chr21:39086157-39087349,
chr21:38800000-38825000~~chr21:39050000-39075000,
chr21:38800000-38825000~~chr21:39075000-39100000,
chr21:38804148-38807306~~chr21:39086131-39087401,
chr21:38804598-38805801~~chr21:39086120-39087303,
chr21:38850000-38875000~~chr21:39050000-39075000,
chr21:38875000-38900000~~chr21:39050000-39075000,
chr21:38900000-38925000~~chr21:39050000-39075000,
chr21:38900000-38925000~~chr21:39075000-39100000,
chr21:38925000-38950000~~chr21:39050000-39075000,
chr21:38950000-38975000~~chr21:39050000-39075000,