Deatailed information for cohesin site CDBP00419391

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  • Basic information
  • CohesinDB ID: CDBP00419391
  • Locus: chr21-39082316-39090007
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, GSE25021, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE143937, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE93080, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, GSE112028, ENCSR703TNG, GSE116344, GSE94872, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000EHX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE131956, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS
  • Cell type: MDM, RH4, GM2610, GM19240, HSPC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, Hep-G2, A-549, HUVEC, HCAEC, GM19238, HeLa, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 43% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.444
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 96% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 29%, "15_Quies": 21%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, TRIM25, SOX2, XBP1, KDM4B, FOXA1, HLF, SUZ12, RBFOX2, RXRB, ZFHX2, TFAP4, ATF3, NFIC, ZC3H8, ZFP64, THAP1, CTCFL, CHD7, PRDM1, CBFB, PAX5, TP63, MITF, CDX2, JMJD1C, MAF, TEAD1, SNAI2, ZNF217, ESR1, CTCF, TCF12, JUN, EP300, BAF155, SOX5, E2F6, DMAP1, E2F4, E2F1, SMC1, TEAD4, FOXA3, GATAD2A, RBPJ, TFAP2C, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, TOP2A, RUNX1T1, ZBTB48, ZSCAN5A, STAT1, SRF, SAP130, ERG2, HNF4G, ERG, ASCL1, OGG1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, PRDM14, IKZF1, RCOR1, NFE2, ZNF639, NR2F6, DACH1, NR3C1, CEBPB, ZNF750, ESRRA, KMT2A, CREB1, CCAR2, EZH2, TBL1XR1, GRHL2, GABPB1, SPI1, TFE3, MIXL1, IRF1, HDAC2, GATA2, SIX2, SREBF1, FLI1, DRAP1, NFIL3, ETV5, PTBP1, RUNX1, THAP11, CBX1, BCL6, CEBPA, MAFG, SMC1A, SIRT6, SIN3A, ZFX, SOX13, SMAD3, ZNF214, TET2, ERG3, CBX8, SP5, TRIM22, SMARCC1, CREBBP, ZNF384, ZXDC, RARA, NOTCH1, NRF1, PBX4, TFDP1, ARNT, ATF2, PRDM9, SMAD4, ZNF48, FOS, MED1, TEAD3, ZEB1, CEBPD, MYB, ZNF264, PIAS1, SMAD1, C11orf30, MAFK, SP1, BCL11A, HNF4A, IKZF5, REST, ZBTB7A, ARID1A, ASH2L, HNRNPLL, FOXP1, AATF, SMC3, STAG1, STAG2, ZNF283, TRP47, PPARG, FOXA2, ZNF316, TBL1X, CHD2, WT1, MAFF, ZBTB33, ZNF823, ZNF580, HOXB13, KDM1A, YY1, RELA, ZNF19, ZNF148, JUNB, SP140, TCF4, HIF1A, ZFP36, BHLHE22, GATA3, MAX, NRIP1, ZNF143, MTA1, CEBPG, KLF4, NCOA3, NR2F2, NR2F1, KDM5B, TP53, NFKB1, EGR2, BRD2, KAT8, ARID4B, AR, TAF1, RXR, EGR1, HSF1, NCOR1, ZBTB26, BRD4, JUND, RNF2, MAZ, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): ETS2
  • Function elements
  • Human SNPs: Ulcerative_colitis_vs_rheumatoid_arthritis_(ordinary_least_squares_(OLS))
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 36
  • Related genes and loops
  • Related gene: ENSG00000157557,
  • Related loop: chr21:17425000-17450000~~chr21:39075000-39100000, chr21:38732732-38735278~~chr21:39086152-39087364, chr21:38732774-38735251~~chr21:39086169-39087327, chr21:38732867-38735207~~chr21:39088403-39089864, chr21:38732918-38735320~~chr21:39083341-39084889, chr21:38732918-38735320~~chr21:39086131-39087401, chr21:38733392-38735200~~chr21:39086157-39087349, chr21:38800000-38825000~~chr21:39075000-39100000, chr21:38804148-38807306~~chr21:39086131-39087401, chr21:38804598-38805801~~chr21:39086120-39087303, chr21:38900000-38925000~~chr21:39075000-39100000,
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