- Basic information
- CohesinDB ID: CDBP00419394
- Locus: chr21-39092794-39099185
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE143937, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE93080, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE106870, GSE145327, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR635OSG, ENCSR984DZW, GSE97394, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, GSE73207
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Cell type: MDM, RH4, GM10847, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, Monocytes, GM18505, TF-1, GM12878, GM12891, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, THP-1, HEK293T, Hep-G2, A-549, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 30% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.433
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 32%,
"7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, KDM3A, ZBTB44, TEAD1, LMO2, OCA2, ZNF561, SOX5, RFX3, KMT2B, GATAD2A, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, STAT1, SAP130, ERG, ZBTB21, SMARCA4, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, CEBPB, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, NR2C2, RUNX1, CEBPA, HDAC1, TET2, TBX3, SP5, ZNF549, SMARCC1, PRDM10, ZXDC, ZBTB2, SOX11, ATF2, FOXM1, SMARCB1, PML, TERF1, PIAS1, ZNF331, C11orf30, EVI1, STAT5A, IKZF5, OVOL3, AFF1, MBD2, ETV4, NFATC3, CBFA2T2, CREM, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, BATF, SPIB, PLAG1, KLF4, BCL11B, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, XBP1, HNF1A, ZNF101, PBX2, ZNF596, TSC22D4, ATF3, THRB, ZFP64, WDHD1, CBFB, TP63, BACH2, JMJD1C, ELF1, ZNF573, KLF10, CTCF, JUN, MNT, DPF2, ZNF423, PDX1, RBPJ, MLX, TFAP2C, ZSCAN21, MTA2, ZBTB48, ZNF317, SRF, NBN, TSHZ1, HOMEZ, RXRA, NKX3-1, PRDM14, MIER3, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, KLF8, EBF3, ZSCAN29, NFIL3, THAP11, SOX13, ZNF770, ZMIZ1, ZNF18, ARNT, BACH1, NFIB, ZNF48, ZEB2, MAFB, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, ZNF680, ZNF41, TBX5, SP1, BCL11A, TFAP2A, NKX2-5, ATF7, ASH2L, CTBP2, PRDM6, SMC3, MLLT1, STAG1, ZNF394, TRP47, MTA3, MEIS1, MAFF, ZNF580, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, TP53, PHOX2B, PHF5A, KAT8, EGR1, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, PGR, PATZ1, TFAP4, BMI1, CHD7, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, TRIM24, GLIS1, POU2F2, ZSCAN5D, ZBTB1, ZSCAN5A, ERG2, HIC1, TBP, HNF4G, OGG1, ETS1, MYC, ARID1B, MCRS1, GABPA, STAT3, IKZF1, GFI1, EZH2, ZNF652, NFE2L1, SPI1, HDAC2, GATAD2B, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, MYBL2, RARA, ZNF384, ZNF35, CREBBP, NFYC, SMAD4, ZNF518A, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, ZNF22, RBM22, MAFK, HNF4A, NR4A1, REST, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF34, PPARG, ZNF692, ZNF30, ZNF574, TCF7, ZNF318, FOXO3, RELA, TARDBP, ZNF282, MAX, GFI1B, NR2F1, TCF7L2, PKNOX1, AR, PAX3-FOXO1, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, ZNF391, HMG20A, LCORL, ZSCAN5C, E2F7, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, ZNF362, HDAC3, CDX2, ZNF629, TRIM28, RCOR2, MLL, MBD4, TCF12, EP300, BAF155, GATA6, PRDM4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, MYCN, RUNX1T1, ZNF205, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, FEZF1, HES1, TFE3, HBP1, IRF1, ZGPAT, ATF1, SMC1A, MAFG, CBX1, SIRT6, FIP1L1, ZFX, SMAD3, CBX8, PRPF4, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, NRF1, FOS, MED1, CEBPD, MYB, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, GLI2, CCNT2, POU2F3, PHIP, SKI, ZNF283, KLF13, FOXA2, E2F8, MIER2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ZNF610, SP140, HIF1A, OTX2, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF843, NFKBIZ, BHLHE40, ZBTB42, MAZ, MEF2D, ZNF24
- Target gene symbol (double-evidenced CRMs): ETS2
- Function elements
- Human SNPs: Red_cell_distribution_width
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 30
- Related genes and loops
- Related gene:
ENSG00000157557,
- Related loop:
chr21:17425000-17450000~~chr21:39075000-39100000,
chr21:38375000-38400000~~chr21:39100000-39125000,
chr21:38450000-38475000~~chr21:39100000-39125000,
chr21:38500000-38525000~~chr21:39100000-39125000,
chr21:38525000-38550000~~chr21:39100000-39125000,
chr21:38700000-38725000~~chr21:39100000-39125000,
chr21:38725000-38750000~~chr21:39100000-39125000,
chr21:38732867-38735207~~chr21:39088403-39089864,
chr21:38750000-38775000~~chr21:39100000-39125000,
chr21:38800000-38825000~~chr21:39075000-39100000,
chr21:38800000-38825000~~chr21:39100000-39125000,
chr21:38850000-38875000~~chr21:39100000-39125000,
chr21:38875000-38900000~~chr21:39100000-39125000,
chr21:38900000-38925000~~chr21:39075000-39100000,
chr21:38925000-38950000~~chr21:39100000-39125000,
chr21:38950000-38975000~~chr21:39100000-39125000,
chr21:39100000-39125000~~chr21:39700000-39725000,