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Basic information

CohesinDB ID: CDBP00419397

Locus: chr21-39103549-39109094

Data sourse: ENCSR000BTQ, ENCSR000EFJ, GSE67783, GSE72082, GSE86191, ENCSR501LQA, GSE98367, ENCSR000HPG, ENCSR879KXD, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE68388, GSE111537, GSE131606, GSE126755, GSE165895

Cell type: MCF-7, Macrophage, RPE, Fibroblast, HCT-116, Monocytes, A-549, OCI-AML-3, IMR-90, K-562, Neutrophil, HSPC, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 7% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.844

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 41%, "7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, ZNF496, HMG20A, NME2, MEIS2, XBP1, ZNF616, FOXA1, HLF, SUZ12, RBFOX2, RXRB, PBX2, HDGF, BMI1, ATF3, THRB, ZFP64, CHD7, PRDM1, ATF4, MXD4, SMARCE1, TP63, ZNF320, JMJD1C, ELF1, BCLAF1, TRIM28, RBM39, TEAD1, NFE2L2, RCOR2, ESR1, LMO2, TP73, USF2, CTCF, JUN, TCF12, EP300, E4F1, KLF1, SOX5, DPF2, DMAP1, TRIM24, U2AF2, ZNF512B, ZNF528, FOXA3, ZNF175, GATAD2A, EHMT2, RBPJ, TFAP2C, MLX, YBX1, CHD8, BRD1, ZSCAN5D, ZNF239, ZNF263, TOP2A, POU5F1, MYCN, CTBP1, ZSCAN21, MTA2, ASH1L, DUX4, STAT1, ZSCAN5A, NONO, MLLT3, GATAD1, DDX5, SAP130, ZBTB48, PHB2, ERG, SMARCC2, MYC, SMARCA4, RFX1, HOMEZ, RAD21, ARID1B, GRHL3, STAT3, ZNF614, XRCC5, PRDM14, IKZF1, RCOR1, NFE2, ZNF639, MIER3, VDR, NR2F6, NR3C1, CEBPB, SRSF3, KMT2A, CREB1, CCAR2, ARHGAP35, ZNF652, NFE2L1, SPI1, TFE3, MIXL1, HDAC2, GATA2, ZNF644, GATAD2B, DRAP1, ZGPAT, NFIL3, ZNF554, ATF1, CC2D1A, RUNX1, THAP11, SMC1A, MAFG, HDAC1, CEBPA, BCL6, EZH2phosphoT487, SIN3A, SOX13, ZFX, ZNF770, CBX8, NFXL1, SP5, TET2, SMARCC1, TWIST1, MYBL2, ZBTB2, RARA, NOTCH1, ZNF384, CREBBP, RUNX2, CDK6, ZNF184, PBX4, NFIB, NRF1, BACH1, ARNT, ZNF48, PRDM9, SMAD4, FOS, CDK8, CHD1, MED1, TEAD3, CEBPD, MYB, ZNF680, U2AF1, C11orf30, L3MBTL2, MAFK, SP1, BCL11A, USF1, REST, ZBTB7A, PHIP, BCOR, FOXP1, SMC3, STAG1, NFATC3, TRP47, PPARG, ZNF207, MTA3, FOXA2, CBX3, SS18, MEIS1, MIER2, GTF2B, MAFF, WT1, ZNF662, MEF2C, CDK9, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, JUNB, AHR, SP140, ZIC2, HIF1A, TAL1, MAX, GATA1, MTA1, ZNF143, CEBPG, NCOA3, NR2F2, ZNF512, ZNF791, KDM5B, PKNOX1, ZNF334, NFKB1, ELF3, KAT8, BHLHE40, AR, ARID4B, ZBTB16, ZNF366, ZBTB26, HSF1, RNF2, BRD4, NOTCH3, MAZ, ZSCAN23, IRF9, ZNF24, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): ETS2,ERG

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 40

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557,

eachgene

Deatailed information for cohesin site CDBP00419397