- Basic information
- CohesinDB ID: CDBP00419399
- Locus: chr21-39114686-39116256
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Data sourse: ENCSR000EFJ, ENCSR853VWZ, GSE131606, GSE67783, ENCSR000BKV, GSE86191, ENCSR000HPG, GSE111913, GSE206145, GSE206145-NatGen2015, GSE68388, GSE112028, ENCSR495WGO, GSE108869, GSE165895
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Cell type: RPE, Fibroblast, HCT-116, A-549, HeLa-S3, RT-112, IMR-90, HSPC, K-562, HeLa-Tet-On, HFFc6, HuCC-T1, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.856
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 52%,
"7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, ZNF496, SOX2, MEIS2, XBP1, FOXA1, PBX2, ZNF90, ATF3, NFIC, ZFP64, MECOM, TEAD1, NFE2L2, LMO2, ESR1, OCA2, TP73, HDAC8, JUN, TCF12, CTCF, EP300, DPF2, SOX4, E2F1, TEAD4, PDX1, TFAP2C, GLIS1, CHD8, BRD1, MYCN, ZNF263, TOP2A, ZBTB48, STAT1, SRF, ARID3A, TBP, HOXC5, ERG, MYC, SMARCA4, ARID1B, RAD21, RXRA, STAT3, ZNF614, XRCC5, IKZF1, NFE2, RCOR1, VDR, NR3C1, CEBPB, CREB1, EBF3, ZHX2, SPI1, GATA2, MXI1, MRTFB, ETV5, RUNX1, SMC1A, MAFG, CEBPA, SOX13, ZFX, SMAD3, TET2, ERG3, SP5, TWIST1, SMARCC1, PRDM10, ZNF384, RUNX2, PBX4, DAXX, NRF1, ATF2, SMAD4, CBFA2T3, PBX3, FOS, CDK8, MED1, TEAD3, CEBPD, SMAD1, SUPT16H, C11orf30, SREBF2, MAFK, BCL11A, ZBTB7A, ZNF479, CTBP2, BCOR, SMC3, STAG1, FOXA2, TBL1X, CBX3, MEIS1, SS18, ZNF600, WT1, MEF2C, ZBTB33, KDM1A, YY1, RELA, JUNB, SP140, ZIC2, GATA3, TAL1, MAX, GATA1, ZNF143, HAND2, CEBPG, NCOA3, GFI1B, KDM5B, TP53, PKNOX1, BRD2, T, AR, YAP1, HSF1, RNF2, ZBTB26, JUND, BRD4, MAZ, TBX2, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): ETS2,ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 3
- Related genes and loops
- Related gene:
ENSG00000157554,
ENSG00000157557,
- Related loop:
chr21:38375000-38400000~~chr21:39100000-39125000,
chr21:38450000-38475000~~chr21:39100000-39125000,
chr21:38500000-38525000~~chr21:39100000-39125000,
chr21:38525000-38550000~~chr21:39100000-39125000,
chr21:38700000-38725000~~chr21:39100000-39125000,
chr21:38725000-38750000~~chr21:39100000-39125000,
chr21:38732922-38735240~~chr21:39120293-39121764,
chr21:38733109-38735129~~chr21:39114383-39115550,
chr21:38750000-38775000~~chr21:39100000-39125000,
chr21:38800000-38825000~~chr21:39100000-39125000,
chr21:38804026-38806194~~chr21:39120537-39121759,
chr21:38804094-38806437~~chr21:39120295-39121683,
chr21:38804159-38806544~~chr21:39120293-39121764,
chr21:38850000-38875000~~chr21:39100000-39125000,
chr21:38875000-38900000~~chr21:39100000-39125000,
chr21:38925000-38950000~~chr21:39100000-39125000,
chr21:38950000-38975000~~chr21:39100000-39125000,
chr21:39100000-39125000~~chr21:39700000-39725000,