Browse_each

Basic information

CohesinDB ID: CDBP00419411

Locus: chr21-39159537-39161498

Data sourse: GSE118494, GSE206145-GSE177045, GSE67783, GSE86191, GSE206145, ENCSR153HNT, GSE25021, GSE50893, GSE73207

Cell type: MCF-7, RPE, HCT-116, Hep-G2, TF-1, IMR-90, K-562, GM19239, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 70%, "7_Enh": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, NME2, XBP1, FOXA1, PBX2, ATF3, THAP1, JMJD1C, TRIM28, LMO2, ESR1, OCA2, USF2, CTCF, GATA6, SOX4, IRF4, ZNF528, TEAD4, RBPJ, TFAP2C, POU2F2, CHD8, ZSCAN5D, ZNF263, MYCN, TOP2A, RUNX1T1, POU5F1, KDM4C, CTBP1, ZBTB48, SAP130, ERG, ASCL1, MYC, EZH1, ARID1B, RAD21, GRHL3, XRCC5, ZNF614, IKZF1, RCOR1, NR3C1, CEBPB, CREB1, GRHL2, EBF3, SPI1, MIXL1, IRF1, GATA2, ZNF644, MXD3, HCFC1R1, NCOA2, ETV5, RUNX1, SMC1A, BCL6, CEBPA, SIRT6, ZFX, TET2, CREBBP, GATA4, ZNF48, SMAD4, CDK8, MED1, TEAD3, ZNF680, C11orf30, L3MBTL2, TBX5, SETDB1, STAT5A, MAFK, BCL11A, HNF4A, NKX2-5, FOXP1, AATF, SMC3, STAG1, TRP47, CBFA2T2, AGO1, FOXA2, ZSCAN16, MAFF, WT1, FOXF1, ZNF580, YY1, RELA, NEUROD1, AHR, SP140, TCF4, OTX2, GATA3, TAL1, MAX, NRIP1, GATA1, PLAG1, NCOA3, NR2F2, NEUROG2, TCF7L2, NR2F1, ZNF334, MYOD1, ELF3, AR, HSF1, ZBTB26, NOTCH3, BRD4, JUND, RNF2, CLOCK, MAZ, ZNF316

Target gene symbol (double-evidenced CRMs): ERG,GET1-SH3BGR,GET1,KCNJ6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 18

Related genes and loops

Related gene: ENSG00000157542, ENSG00000157554, ENSG00000285815, ENSG00000182093,

eachgene

Deatailed information for cohesin site CDBP00419411