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Basic information

CohesinDB ID: CDBP00419416

Locus: chr21-39180628-39180930

Data sourse: GSE138405, GSE110061, GSE50893, ENCSR000BMY

Cell type: Hela-Kyoto, GM12878, HCT-116, GM12891

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 63%, "4_Tx": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, SOX5, PAX8, ZNF407, E2F4, DEK, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, BRD3, TOP2A, POU5F1, CTBP1, ZMYND11, STAT1, SAP130, ERG, ZBTB8A, EZH1, SMARCA4, RFX1, DNMT1, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CD74, CEBPB, HNRNPL, RBM34, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, NR2C2, MXI1, ZNF785, DRAP1, RELB, EP400, RUVBL2, RUNX1, CEBPA, HDAC1, NKX2-2, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ATF2, SNIP1, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, MBD1, GSPT2, ARID2, IKZF5, OVOL3, RBM25, MBD2, ELL2, NFATC3, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, TCF4, ZFP36, MAF1, PLAG1, ZFP69B, BCL11B, KLF4, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, SRSF4, PBX2, HNRNPK, CDK2, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, ZSCAN4, TP63, MITF, ZNF780A, MAF, INTS11, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, TAF3, JUN, MNT, ZBTB20, LMO1, RYBP, DPF2, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MLX, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, ZNF317, NONO, SRF, NBN, KDM4A, ZNF2, TSHZ1, FOXP2, HOMEZ, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, CCAR2, TBL1XR1, KLF8, GRHL2, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, ZNF585A, EZH2phosphoT487, AFF4, SOX13, POU4F2, ZNF770, ZNF513, ZMIZ1, ZNF792, ZNF18, SP3, NFIB, DAXX, ARNT, BACH1, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, ETV6, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, ZBTB18, TBX5, USF1, BCL11A, TFAP2A, SP1, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, MLLT1, STAG1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, KLF7, KAT2B, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF334, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, TFAP4, SIN3B, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, TP73, ZNF524, KLF1, ZNF695, SOX9, E2F6, TRIM24, RFX5, U2AF2, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZBTB1, ZSCAN5A, ERG2, SP4, HIC1, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, ZNF24, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF777, ZNF76, NCOA2, ETV5, BCL6, SIN3A, ZFP37, ERG3, MEF2A, RARA, ZNF384, NFYC, CREBBP, TAF15, ZNF35, ZNF133, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, GTF3C2, SREBF2, ZNF22, RBM22, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, HOXA9, ZNF543, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF574, TCF7, YY2, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, ZNF791, NEUROG2, PKNOX1, RUVBL1, MYOD1, T, KMT2D, AR, YAP1, ZNF324, HEXIM1, AHR, DMAP1, MBD3, FOSL2, ZNF391, HMG20A, E2F7, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, ZNF362, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, MLLT3, GATAD1, GMEB2, ARID3A, ZNF585B, ASCL1, MIER1, ZNF341, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF750, FEZF1, HES1, TFE3, HBP1, ZNF664, IRF1, EHF, SREBF1, GTF3C5, ZGPAT, MRTFB, ZIM3, MYF5, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, NRF1, PBX4, SUPT5H, CHD1, FOS, TGIF2, MED1, CEBPD, KDM6B, SCRT2, MYB, ZNF558, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NUP98-HOXA9, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, HIF1A, OTX2, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF837, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): BRWD1,ETS2,KCNJ6,GET1,ERG,SH3BGR,PSMG1,GET1-SH3BGR,LCA5L,HMGN1,B3GALT5

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157542, ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000185658, ENSG00000205581, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000185437, ENSG00000183778,

eachgene

Deatailed information for cohesin site CDBP00419416